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运动学习时通过神经胶质突触吞噬进行突触修剪帮助记忆形成
作者:小柯机器人 发布时间:2022/11/5 17:15:39

日本东北大学Ko Matsui和Yosuke M. Morizawa共同合作近期取得重要工作进展,他们研究发现在运动学习时通过神经胶质突触吞噬进行突触修剪帮助记忆形成。相关论文于2022年11月1日在线发表于《自然—神经科学》杂志上。

利用新开发的吞噬报告小鼠和三维超微结构特征,研究人员发现小脑伯格曼胶质(BG)在小脑依赖性运动学习时经常发生突触吞噬现象。研究人员观察到BG突触前和突触后啃食增加,学习后脊柱体积减少。Annexin V的药物阻断抑制了脊柱体积缩小和夜间运动适应性的改善。结果表明,BG在运动学习过程中通过突触吞噬促进成熟小脑皮层回路的完善。

据介绍,突触修剪是学习和记忆中神经元回路细化的一个基本过程。越来越多的证据表明,神经胶质细胞通过吞噬突触参与塑造神经元回路的过程。然而,神经胶质参与的突触修剪是否在记忆形成中起作用仍是未知的。

附:英文原文

Title: Synaptic pruning through glial synapse engulfment upon motor learning

Author: Morizawa, Yosuke M., Matsumoto, Mami, Nakashima, Yuka, Endo, Narumi, Aida, Tomomi, Ishikane, Hiroshi, Beppu, Kaoru, Moritoh, Satoru, Inada, Hitoshi, Osumi, Noriko, Shigetomi, Eiji, Koizumi, Schuichi, Yang, Guang, Hirai, Hirokazu, Tanaka, Kohichi, Tanaka, Kenji F., Ohno, Nobuhiko, Fukazawa, Yugo, Matsui, Ko

Issue&Volume: 2022-11-01

Abstract: Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and memory. Accumulating evidence suggests that glia participates in sculpting the neuronal circuits through synapse engulfment. However, whether glial involvement in synaptic pruning has a role in memory formation remains elusive. Using newly developed phagocytosis reporter mice and three-dimensional ultrastructural characterization, we found that synaptic engulfment by cerebellar Bergmann glia (BG) frequently occurred upon cerebellum-dependent motor learning in mice. We observed increases in pre- and postsynaptic nibbling by BG along with a reduction in spine volume after learning. Pharmacological blockade of engulfment with Annexin V inhibited both the spine volume reduction and overnight improvement of motor adaptation. These results indicate that BG contribute to the refinement of the mature cerebellar cortical circuit through synaptic engulfment during motor learning.

DOI: 10.1038/s41593-022-01184-5

Source: https://www.nature.com/articles/s41593-022-01184-5

期刊信息

Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新IF:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex