厦门大学徐海超团队报道了光电化学不对称催化实现直接和对映选择性脱羧氰化。相关研究成果发表在2022年10月31日出版的《美国化学会杂志》。

由于羧酸的易得性和无毒性，开发高效和可持续的脱羧转化方法非常重要。尽管在这一领域做出了巨大研究，但直接从羧酸中开发对映选择性转化仍然具有挑战性。

该文中，研究人员报道了一种用于直接和对映选择性脱羧氰化的光电催化方法。光电化学反应通过使用铈/铜中继催化将羧酸转化为对映体富集的腈，铈盐用于催化脱羧，手性铜络合物用于立体选择性形成C–CN。

附：英文原文

Title: Photoelectrochemical Asymmetric Catalysis Enables Direct and Enantioselective Decarboxylative Cyanation

Author: Xiao-Li Lai, Ming Chen, Yuqi Wang, Jinshuai Song, Hai-Chao Xu

Issue&Volume: October 31, 2022

Abstract: The development of efficient and sustainable methods for decarboxylative transformations is of great importance due to the ease of availability and nontoxicity of carboxylic acids. Despite tremendous efforts in this area, it remains challenging to develop enantioselective transformations direct from carboxylic acids. Herein we disclose a photoelectrocatalytic method for the direct and enantioselective decarboxylative cyanation. The photoelectrochemical reactions convert carboxylic acids to enantioenriched nitriles by employing cerium/copper relay catalysis with a cerium salt for catalytic decarboxylation and a chiral copper complex for stereoselective C–CN formation.

DOI: 10.1021/jacs.2c09050

Source: https://pubs.acs.org/doi/10.1021/jacs.2c09050