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研究揭示了衰老和社会环境的特征
作者:小柯机器人 发布时间:2022/11/26 16:54:04

美国亚利桑那州立大学Noah Snyder-Mackler等研究组合作利用灵长类动物大脑的多区域转录组分析揭示衰老和社会环境的特征。2022年11月24日出版的《自然—神经科学》发表了这项成果。

为了了解灵长类动物大脑衰老的轨迹,他们在一个自由放养的、行为表型的恒河猴独特种群中生成了一个多区域批量(N = 527个样本)和单核(N = 24个样本)大脑转录数据集,包括15个大脑区域和两种性别。他们证明,与年龄相关的基因表达水平和变异发生在与神经功能和神经疾病相关的基因中,包括阿尔茨海默病。

此外,他们还发现,女性较高的社会地位与较年轻的相对转录年龄相关,提供了社会环境与大脑衰老之间的联系。他们的发现有助于深入了解人类行为、认知和健康的非人类灵长类动物模型中大脑衰老的生物机制。

据介绍,衰老伴随着一系列社会和生物变化,这些变化与行为、认知健康和对神经退行性疾病的易感性有关。

附:英文原文

Title: Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment

Author: Chiou, Kenneth L., DeCasien, Alex R., Rees, Katherina P., Testard, Camille, Spurrell, Cailyn H., Gogate, Aishwarya A., Pliner, Hannah A., Tremblay, Sbastien, Mercer, Arianne, Whalen, Connor J., Negrn-Del Valle, Josu E., Janiak, Mareike C., Bauman Surratt, Samuel E., Gonzlez, Olga, Compo, Nicole R., Stock, Michala K., Ruiz-Lambides, Angelina V., Martnez, Melween I., Wilson, Melissa A., Melin, Amanda D., Antn, Susan C., Walker, Christopher S., Sallet, Jrme, Newbern, Jason M., Starita, Lea M., Shendure, Jay, Higham, James P., Brent, Lauren J. N., Montague, Michael J., Platt, Michael L., Snyder-Mackler, Noah

Issue&Volume: 2022-11-24

Abstract: Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to neurodegenerative disease. To understand trajectories of brain aging in a primate, we generated a multiregion bulk (N=527 samples) and single-nucleus (N=24 samples) brain transcriptional dataset encompassing 15 brain regions and both sexes in a unique population of free-ranging, behaviorally phenotyped rhesus macaques. We demonstrate that age-related changes in the level and variance of gene expression occur in genes associated with neural functions and neurological diseases, including Alzheimer’s disease. Further, we show that higher social status in females is associated with younger relative transcriptional ages, providing a link between the social environment and aging in the brain. Our findings lend insight into biological mechanisms underlying brain aging in a nonhuman primate model of human behavior, cognition and health.

DOI: 10.1038/s41593-022-01197-0

Source: https://www.nature.com/articles/s41593-022-01197-0

期刊信息

Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新IF:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex