华中师范大学尹军团队报道了杂氮包覆七甲基花青色素NaCl处理形成J聚合体及其在监测植物盐胁迫和促进肿瘤光热治疗中的应用。相关研究成果于2022年11月21日发表在《德国应用化学》。

七甲基花青色素的阳离子性质使其能够通过静电相互作用与盐形成聚集体。

该文中，NaCl促进了氮包覆七甲基花青色素J聚集体的形成。NaCl可以诱导N-苄氧羰基Cy-CO2Bz组装成在890nm处具有吸收的J聚集体。它对NaCl的优异荧光响应表明，其有很大的潜力用作植物盐胁迫的探针。此外，NaCl还促进N-乙氧基羰基Cy-CO2Et形成J聚集体。与在766nm处吸收的单体相比，聚集体在910nm处显示出强烈的吸收。其J聚集形式可以用作光热剂。光热转换效率从29.37%提高到57.59%。

这一努力导致了新的花青J聚集体的两种应用的发展，包括一种用于追踪植物的盐胁迫，另一种用于促进肿瘤的光热治疗。

附：英文原文

Title: J-Aggregates Formed by NaCl Treatment of Aza-Coating Heptamethine Cyanines and Their Application to Monitoring Salt Stress of Plants and Promoting Photothermal Therapy of Tumors

Author: Xiaoxie Ma, Yurou Huang, Weijie Chen, Jia Liu, Sheng Hua Liu, Jun Yin, Guang-Fu Yang

Issue&Volume: 2022-11-21

Abstract: The cationic nature of heptamethine cyanines gives them the capacity to form aggregates with salts by electrostatic interactions. In this work, NaCl promoted J-aggregate formation of aza-coating heptamethine cyanines is explored. NaCl can induce the N-benzyloxycarbonyl Cy-CO2Bz to assemble into a J-aggregate having an absorption at 890 nm. Its excellent fluorescence response to NaCl implies that it has great potential for use as a probe for tracing salt stress in plants. Moreover, NaCl also promotes formation of J-aggregates from the N-ethyloxycarbonyl Cy-CO2Et. The aggregate shows an intense absorption at 910 nm compared to the monomer which absorbs at 766 nm. Its J-aggregated form can serve as a photothermal agent. And the photothermal conversion efficiency is increased from 29.37% to 57.59%. This effort leads to the development of two applications of new cyanine J-aggregates including one for tracing salt stress of plants and the other for promoting photothermal therapy of tumors.

DOI: 10.1002/anie.202216109

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202216109