东华大学储玲玲团队报道了磷自由基实现炔光诱导发散氰化。相关研究成果发表在2022年10月20日出版的《德国应用化学》。

该文描述了一种由磷自由基引发的炔烃的光化学诱导的选择性和发散氰化反应。使用简单的三芳基膦作为助催化剂，可以不同程度地实现三个氰化反应，包括二氢氰化、反Markovnikov氢氰化和多米诺氢氰化/还原，在温和条件下制备大量烷基二腈、烯基腈和烷基腈。末端和内部炔烃适用于高效和优异的选择性。

该文还报道了生物活性剂的合成应用以及初步的实验和计算机理研究。

附：英文原文

Title: Light-Induced Divergent Cyanation of Alkynes Enabled by Phosphorus Radicals

Author: Yanyan Zhang, Yunhong Han, Shengqing Zhu, Feng-Ling Qing, Xiao-Song Xue, Lingling Chu

Issue&Volume: 2022-10-20

Abstract: A photochemically induced selective and divergent cyanation reaction of alkynes, enabled by phosphorus radicals, is described. With the use of simple triarylphosphine as a co-catalyst, three cyanation reactions, including di-hydrocyanation, anti-Markovnikov hydrocyanation, and domino hydrocyanation/reduction, can be divergently achieved, furnishing a wide array of alkyl dinitriles, alkenyl nitriles, and alkyl nitriles under mild conditions. Terminal and internal alkynes are applicable with high efficiency and excellent selectivity. Synthetic applications for biologically active agents and preliminary experimental and computational mechanistic studies are reported.

DOI: 10.1002/anie.202210838

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202210838