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研究揭示恢复力的行为和多巴胺能特征
作者:小柯机器人 发布时间:2022/10/23 14:53:02

美国普林斯顿大学Annegret L. Falkner等研究人员合作揭示恢复力的行为和多巴胺能特征。相关论文于2022年10月19日在线发表在《自然》杂志上。

研究人员记录了小鼠的行为和多巴胺(DA)神经元在社会失败期间向伏隔核(NAc)(其发出奖励信号)和尾纹状体(TS)(其发出威胁信号)的投影活动。有监督和无监督的行为量化显示,在压力期间,有弹性和易受影响的小鼠使用不同的行为策略,在NAc(但不是TS)的DA终端有不同的活动模式。在神经上,有恢复力的小鼠在攻击者附近有更大的活动,包括在开始反击的时候。相反,易受影响的小鼠在攻击的偏移和逃跑的开始时有更大的活动。

研究人员还对NAc投射的DA神经元进行了光遗传学刺激,这些神经元在战败期间处于开环状态(随机计时),或利用实时行为分类对特定行为进行计时。开环和反击定时的激活都促进了恢复力,并在失败期间将行为重组为与恢复力相关的模式。总之,这些数据提供了压力体验期间DA神经活动、恢复力和恢复力相关行为之间的联系。

据介绍,慢性压力会对一些人产生持久的不良后果,然而另一些人对同一压力源却有恢复力。在压力体验结束后,易受影响的人和有恢复力的人在中脑边缘DA神经元的内在属性方面表现出差异。然而,DA、压力期间的行为和复原力的个体差异之间的因果关系是未知的。

附:英文原文

Title: Behavioural and dopaminergic signatures of resilience

Author: Willmore, Lindsay, Cameron, Courtney, Yang, John, Witten, Ilana B., Falkner, Annegret L.

Issue&Volume: 2022-10-19

Abstract: Chronic stress can have lasting adverse consequences in some individuals, yet others are resilient to the same stressor1,2. Susceptible and resilient individuals exhibit differences in the intrinsic properties of mesolimbic dopamine (DA) neurons after the stressful experience is over3,4,5,6,7,8. However, the causal links between DA, behaviour during stress and individual differences in resilience are unknown. Here we recorded behaviour in mice simultaneously with DA neuron activity in projections to the nucleus accumbens (NAc) (which signals reward9,10,11,12) and the tail striatum (TS) (which signals threat13,14,15,16) during social defeat. Supervised and unsupervised behavioural quantification revealed that during stress, resilient and susceptible mice use different behavioural strategies and have distinct activity patterns in DA terminals in the NAc (but not the TS). Neurally, resilient mice have greater activity near the aggressor, including at the onset of fighting back. Conversely, susceptible mice have greater activity at the offset of attacks and onset of fleeing. We also performed optogenetic stimulation of NAc-projecting DA neurons in open loop (randomly timed) during defeat or timed to specific behaviours using real-time behavioural classification. Both open-loop and fighting-back-timed activation promoted resilience and reorganized behaviour during defeat towards resilience-associated patterns. Together, these data provide a link between DA neural activity, resilience and resilience-associated behaviour during the experience of stress.

DOI: 10.1038/s41586-022-05328-2

Source: https://www.nature.com/articles/s41586-022-05328-2

期刊信息

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html