当前位置:科学网首页 > 小柯机器人 >详情
孟德尔随机化分析支持脑成像衍生表型与精神疾病风险之间的因果关系
作者:小柯机器人 发布时间:2022/10/11 10:32:36

西安交通大学Tie-Lin Yang和Yan Guo共同合作近期取得重要工作进展,他们通过孟德尔随机化分析揭示了脑成像衍生表型与精神障碍风险之间的因果关系。这一研究成果2022年10月10日在线发表于《自然—神经科学》杂志上。

研究人员进行了双向双样本孟德尔随机化(MR)分析,以探讨587个可靠的IDPs(N=33,224人)和10种精神障碍(N=9,725至161,405)之前的因果关系。他们鉴定出了9个有证据表明对精神分裂症、神经性厌食症和双相情感障碍风险有因果影响的IDPs。例如, 胼胝体大钳方向分散指数每增加1个标准差,精神分裂症风险的几率将降低32%。反向MR表明,只有遗传预测的精神分裂症与两个IDP正相关,即皮质表面积和右眼眶旁的体积。研究人员建立了BrainMR数据库(http://www.bigc.online/BrainMR/)来分享他们的结果。他们的发现为在脑成像水平上预测和干预精神障碍风险提供了潜在的策略。

据介绍,观察性研究报道了脑成像衍生表型(IDPs)与精神疾病之间的相关性,然而,这种关系是否是因果关系还不确定。

附:英文原文

Title: Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders

Author: Guo, Jing, Yu, Ke, Dong, Shan-Shan, Yao, Shi, Rong, Yu, Wu, Hao, Zhang, Kun, Jiang, Feng, Chen, Yi-Xiao, Guo, Yan, Yang, Tie-Lin

Issue&Volume: 2022-10-10

Abstract: Observational studies have reported the correlations between brain imaging-derived phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal is uncertain. We conducted bidirectional two-sample Mendelian randomization (MR) analyses to explore the causalities between 587 reliable IDPs (N=33,224 individuals) and 10 psychiatric disorders (N=9,725 to 161,405). We identified nine IDPs for which there was evidence of a causal influence on risk of schizophrenia, anorexia nervosa and bipolar disorder. For example, 1s.d. increase in the orientation dispersion index of the forceps major was associated with 32% lower odds of schizophrenia risk. Reverse MR indicated that only genetically predicted schizophrenia was positively associated with two IDPs, the cortical surface area and the volume of the right pars orbitalis. We established the BrainMR database (http://www.bigc.online/BrainMR/) to share our results. Our findings provide potential strategies for the prediction and intervention for psychiatric disorder risk at the brain-imaging level.

DOI: 10.1038/s41593-022-01174-7

Source: https://www.nature.com/articles/s41593-022-01174-7

期刊信息

Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新IF:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex