西南大学甄淑君团队提出了一种对微弱输入具有强响应的灵敏逻辑纳米器件。相关研究成果于2022年1月5日发表在国际顶尖学术期刊《德国应用化学》。

在开发具有弱输入信号（ISs）的新计算系统时，传感的灵敏至关重要。

该文中，研究人员提出了一种“弱输入-强输出”策略，通过将输入诱导可逆DNA计算平台与基于杂交链式反应的信号放大器耦合，来指导敏感逻辑纳米器件的构建。通过合理设计计算元件序列（CEs）以避免ISs和信号放大器之间的串扰，新形成的逻辑纳米器件即使在低浓度的CEs下也对弱ISs具有良好的灵敏度，并且能够执行YES、OR、NAND、NOR、INHIBIT、INHIBIT-OR和数字分类器操作，表明DNA计算在稀溶液介质中进行，大大提高了逻辑纳米器件的计算能力，而不受纳米技术中光刻工艺的限制。

附：英文原文

Title: Sensitive Logic Nanodevices with Strong Response for Weak Inputs

Author: Wen Yi Lv, Chun Hong Li, Fei Fan Yang, Yuan Fang Li, Shu Jun Zhen, Cheng Zhi Huang

Issue&Volume: 2022-01-05

Abstract: Sensitive sensing is critical when developing new calculation systems with weak input signals (ISs). In this work, a “weak-inputs-strong-outputs” strategy was proposed to guide the construction of sensitive logic nanodevices by coupling input-induced reversible DNA computing platform with hybridization chain reaction-based signal amplifier. By rational design of the sequence of computing elements (CEs) so as to avoid cross-talking between ISs and signal amplifier, the newly formed logic nanodevices have good sensitivity to the weak ISs even at low concentrations of CEs, and are able to perform YES, OR, NAND, NOR, INHIBIT, INHIBIT-OR and number classifier operation, showing that the DNA calculation proceeds in dilute solution medium that greatly prompts the calculation proficiency of logic nanodevices without the confinement of lithography process in nanotechnology.

DOI: 10.1002/anie.202115561

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202115561