山东大学杨志杰团队报道了曲率介导的相互作用引导自组装纳米复合材料的手性反转。相关研究成果于2022年1月3日发表在《德国应用化学》。

纳米尺度曲率相关的相互作用在生物系统中至关重要。

该文中，研究人员报道了纳米尺度曲率在调节手性有机分子和非手性纳米颗粒自组装纳米复合材料的手性方面起着重要作用。具体而言，研究表明纳米复合材料的超分子手性明显取决于纳米颗粒的曲率，其中高曲率的小尺寸纳米颗粒和低曲率的大尺寸纳米颗粒导致具有相反手性的纳米复合材料。

定量动力学实验和分子动力学模拟表明，纳米颗粒曲率在促进手性分子的预成核齐聚反应中起着关键作用，从而调节了纳米复合材料的超分子手性。该项研究将有助于人工合作系统的合理设计，从而产生丰富且通常无法通过研究传统的非合作系统来理解的紧急装配现象。

附：英文原文

Title: Chirality Inversion in Self-Assembled Nanocomposites Directed by Curvature Mediated Interactions

Author: Yanjun Gong, Zhaozhen Cao, Zongze Zhang, Rongjuan Liu, Fenghua Zhang, Jingjing Wei, Zhijie Yang

Issue&Volume: 2022-01-03

Abstract: Nanoscale curvature-dependent interactions are of paramount importance in biological systems. Here, we report that nanoscale curvature plays an important role in regulating the chirality of self-assembled nanocomposites from chiral organic molecules and achiral nanoparticles. Specifically, we show that the supramolecular chirality of the nanocomposites markedly depends on the nanoparticle curvature, where small sized nanoparticles of high curvature and large sized nanoparticles of low curvature lead to nanocomposites with opposite chirality. Quantitative kinetic experiments and molecular dynamics simulations reveal that nanoparticle curvature plays a key role in promoting the pre-nucleation oligomerization of chiral molecules, which consequently regulates the supramolecular chirality of the nanocomposites. We anticipate that this study will aid in rational design of artificial cooperative system giving rise to emergent assembling phenomena that can be surprisingly rich and often cannot be understood by studying the conventional noncooperative systems.

DOI: 10.1002/anie.202117406

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202117406