中国科学技术大学龚流柱团队报道了有机/过渡金属复合催化在不对称合成中充满活力。相关研究成果于2022年1月20日发表在国际知名学术期刊《美国化学会杂志》。

自二十年前问世以来，不对称有机/过渡金属复合催化（AOMC），包括协同催化和接力催化，利用化学键的重新分布来建立分子复杂性和对映体分化，从而通过多种有机催化剂和过渡金属络合物的活化形成单个对映体。

该研究的目标是为读者提供AOMC的基本属性─正交性、动力学、机理和选择性─了解有机催化剂和过渡金属络合物如何协作以实现富有成效的新反应开发，以及非生产性事件（如催化剂自猝灭）的内在途径。最后，AOMC未来的机会主要集中在预测有效的催化剂组合、引入酶催化以及关注瞬时自由基中间体，从而在未来几年使该领域充满活力。

附：英文原文

Title: Organo/Transition-Metal Combined Catalysis Rejuvenates Both in Asymmetric Synthesis

Author: Dian-Feng Chen, Liu-Zhu Gong

Issue&Volume: January 20, 2022

Abstract: Since its advent two decades ago, asymmetric organo/transition-metal combined catalysis (AOMC), including cooperative catalysis and relay catalysis, has leveraged redistribution of chemical bonds to build up molecular complexity and enantio-differentiation to form individual enantiomers with activations from versatile organocatalysts and transition-metal complexes. The goal of this perspective is to provide readers with the fundamental attributes of AOMC─orthogonality, kinetics, mechanism, and selectivity─to understand how an organocatalyst and a transition-metal complex would collaborate to enable fruitful new reaction development and what are the intrinsic pathways of unproductive events, such as catalyst self-quenching. In closing, future opportunities of AOMC have been directed toward the prediction of effective catalyst combination, introducing enzyme catalysis, and a focus on transient radical intermediate, to animate this area in the years to come.

DOI: 10.1021/jacs.1c11408

Source: https://pubs.acs.org/doi/10.1021/jacs.1c11408