2022年1月13日出版的《细胞-代谢》杂志在线发表了丹麦哥本哈根大学Juleen R. Zierath和德国糖尿病研究中心Dominik Lutter课题组合作的研究。他们利用运动代谢图谱揭示了代谢稳态的时间依赖性特征。

为了了解组织如何独立和协同对定时运动做出反应，研究人员采用了系统生物学方法。研究人员绘制并比较了七种不同小鼠在一天不同时间内进行急性运动后组织和血清的全局代谢物反应。组织内和组织间代谢物动力学比较分析揭示了特定时间运动的局部和全身代谢反应；包括对肝脏和后肢肌肉的时间分析和血液采样。

这份全面的运动代谢图谱提供了关于典型和新型时间依赖性运动代谢物（如 2-羟基丁酸 (2-HB)）产生和分布的详细生理背景，并揭示了运动对新陈代谢的益处。

据悉，组织对运动的敏感性和反应因时间和生物钟的排列而异，但尚不清楚引发所需代谢结果的最佳运动时间。

附：英文原文

Title: Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

Author: Shogo Sato, Kenneth A. Dyar, Jonas T. Treebak, Sara L. Jepsen, Amy M. Ehrlich, Stephen P. Ashcroft, Kajetan Trost, Thomas Kunzke, Verena M. Prade, Lewin Small, Astrid Linde Basse, Milena Schnke, Siwei Chen, Muntaha Samad, Pierre Baldi, Romain Barrès, Axel Walch, Thomas Moritz, Jens J. Holst, Dominik Lutter, Juleen R. Zierath, Paolo Sassone-Corsi

Issue&Volume: 2022-01-13

Abstract: Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This comprehensive atlas of exercise metabolism provides clarity and physiological context regarding the production and distribution of canonical and novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), and reveals insight into the health-promoting benefits of exercise on metabolism.

DOI: 10.1016/j.cmet.2021.12.016

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00635-5