香港中文大学唐本忠团队开发了新型喹嗪AIE系统用于分子运动可视化和生物应用的精细剪裁。相关研究成果发表在2022年1月12日出版的《德国应用化学》。

分子运动在自然界中无处不在，它们在所有的行为中都扮演着固有的角色。然而，对于研究人员来说，探索合适的模型来解释分子运动是一项极其重要但极具挑战性的任务。考虑到聚集诱导发射（AIE）发光材料在可视化分子运动方面具有独特的优点，因此构建新的AIE系统作为研究分子运动的模型尤为引人注目。

该文中，基于限制性分子内振动机制，研究人员构建了一种新型喹嗪（QLZ）AIE体系。结果表明，QLZ可以作为一个理想的模型，通过荧光变化来可视化单分子运动和宏观分子运动。此外，对这一令人印象深刻的核心的进一步精心剪裁实现了高效的活性氧物种制备，并实现了荧光成像引导的光动力治疗应用，证实了该新型AIE活性QLZ核心的巨大应用潜力。

研究工作不仅为可视化分子运动提供了一个理想的模型，而且为AIEgens的应用开辟了一条新的途径。

附：英文原文

Title: Novel Quinolizine AIE System: Visualization of Molecular Motion and Elaborate Tailoring for Biological Application

Author: Benzhao He, Jiachang Huang, Jianyu Zhang, Herman H. Y. Sung, Jacky W. Y. Lam, Zhijun Zhang, Saisai Yan, Dong Wang, Jing Zhang, Ben Zhong Tang

Issue&Volume: 2022-01-12

Abstract: Molecular motions are ubiquitous in nature and they immutably play intrinsic roles in all actions. However, exploring appropriate models to decipher molecular motions is an extremely important but very challenging task for researchers. Considering aggregation-induced emission (AIE) luminogens possess their unique merits to visualize molecular motions, it is particularly fascinating to construct new AIE systems as model to study molecular motion. Herein, a novel quinolizine (QLZ) AIE system was constructed based on the restriction intramolecular vibration mechanism. It was demonstrated that QLZ could act as an ideal model to visualize single-molecule motion and macroscopic molecular motion  via  fluorescence change. Additionally, further elaborate tailoring of this impressive core achieved highly efficient reactive oxygen species production and realized fluorescence imaging-guided photodynamic therapy applications, which confirms the great application potential of this new AIE-active QLZ core. Therefore, this work not only provides an ideal model to visualize molecular motion but also opens a new way for the application of AIEgens.

DOI: 10.1002/anie.202117709

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202117709