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海马神经元构建抽象价值空间的地图
作者:小柯机器人 发布时间:2021/8/8 12:31:20

美国加州大学伯克利分校Eric B. Knudsen等研究人员发现,海马神经元构建抽象价值空间的地图。2021年8月3日,《细胞》杂志在线发表了这项成果。

研究人员利用线索的相对奖励价值来定义了通过抽象价值空间的连续"路径",从而表明灵长类动物海马的单个神经元通过价值位置域来编码这个空间,这很像啮齿动物位置神经元编码物理空间的路径。当线索发生变化时,价值位置域会重新定位,而且在不同的环境下变得越来越相关,进而使地图变得普遍化。这项发现有助于解释海马对基于价值决策的关键贡献,并提供了一种机制,世界上的关系知识通过这种机制可以被纳入奖励预测来指导决策。

据介绍,海马被认为是编码"认知地图",这是关于世界关系的知识结构组织。位置细胞是空间选择性的海马神经元,在啮齿类动物中已被广泛研究,是该地图的一个组成部分,并描述了环境特征的相对位置。然而,这种地图是否延伸到抽象的、认知性的信息仍然是未知的。

附:英文原文

Title: Hippocampal neurons construct a map of an abstract value space

Author: Eric B. Knudsen, Joni D. Wallis

Issue&Volume: 2021-08-03

Abstract: The hippocampus is thought to encode a “cognitive map,” a structural organizationof knowledge about relationships in the world. Place cells, spatially selective hippocampalneurons that have been extensively studied in rodents, are one component of this map,describing the relative position of environmental features. However, whether thismap extends to abstract, cognitive information remains unknown. Using the relativereward value of cues to define continuous “paths” through an abstract value space,we show that single neurons in primate hippocampus encode this space through valueplace fields, much like a rodent’s place neurons encode paths through physical space.Value place fields remapped when cues changed but also became increasingly correlatedacross contexts, allowing maps to become generalized. Our findings help explain thecritical contribution of the hippocampus to value-based decision-making, providinga mechanism by which knowledge of relationships in the world can be incorporated intoreward predictions for guiding decisions.

DOI: 10.1016/j.cell.2021.07.010

Source: https://www.cell.com/cell/fulltext/S0092-8674(21)00836-9

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/