当前位置:科学网首页 > 小柯机器人 >详情
单个NK细胞连接先天性和适应性病毒识别
作者:小柯机器人 发布时间:2021/8/28 21:13:10

德国慕尼黑工业大学Simon Grassmann研究组发现单个自然杀伤 (NK) 细胞的命运图谱确定了 1 型先天性淋巴样谱系,该谱系连接了病毒感染的先天性和适应性识别。该研究于2021年8月25日发表于国际一流学术期刊《免疫学》杂志上。

通过对小鼠巨细胞病毒 (MCMV) 感染后单个 NK 细胞的命运图谱,他们确定了两种不同的 NK 细胞谱系,它们有助于适应性样反应。一个相当于传统的 NK (cNK) 细胞,而另一个在转录上类似于 1 型先天淋巴细胞 (ILC1)。ILC1 样 NK 细胞表现出脾驻留和强大的细胞因子产生特性,但也识别和杀死 MCMV 感染的细胞,由激活受体 Ly49H 引导。

此外,它们在 MCMV 感染期间诱导了常规 1 型树突细胞的聚集并促进了抗原特异性 T 细胞的启动,这取决于 Ly49H 和转录因子 Batf3 的 NK 细胞内在表达。因此,ILC1 样 NK 细胞桥接先天和适应性病毒识别,并将 cNK 细胞和 ILC1 的关键特征结合起来。

据了解,在病毒感染后,表达某些种系编码受体的NK细胞以类似适应性的方式被选择、扩增和维持。目前,这些被认为沿着共同的途径分化。

附:英文原文

Title: Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Author: Sophie Flommersfeld, Jan P. Bttcher, Jonatan Ersching, Michael Flossdorf, Philippa Meiser, Ludwig O. Pachmayr, Justin Leube, Inge Hensel, Sebastian Jarosch, Qin Zhang, M. Zeeshan Chaudhry, Immanuel Andrae, Matthias Schiemann, Dirk.H. Busch, Luka Cicin-Sain, Joseph C. Sun, Georg Gasteiger, Gabriel D. Victora, Thomas Hfer, Veit R. Buchholz, Simon Grassmann

Issue&Volume: 2021-08-25

Abstract: Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway. However, by fate mapping of single NK cells upon murine cytomegalovirus (MCMV) infection, we identified two distinct NK cell lineages that contributed to adaptive-like responses. One was equivalent to conventional NK (cNK) cells while the other was transcriptionally similar to type 1 innate lymphoid cells (ILC1s). ILC1-like NK cells showed splenic residency and strong cytokine production but also recognized and killed MCMV-infected cells, guided by activating receptor Ly49H. Moreover, they induced clustering of conventional type 1 dendritic cells and facilitated antigen-specific T cell priming early during MCMV infection, which depended on Ly49H and the NK cell-intrinsic expression of transcription factor Batf3. Thereby, ILC1-like NK cells bridge innate and adaptive viral recognition and unite critical features of cNK cells and ILC1s.

DOI: 10.1016/j.immuni.2021.08.002

Source: https://www.cell.com/immunity/fulltext/S1074-7613(21)00332-0

期刊信息

Immunity:《免疫》,创刊于1994年。隶属于细胞出版社,最新IF:21.522
官方网址:https://www.cell.com/immunity/home
投稿链接:https://www.editorialmanager.com/immunity/default.aspx