克罗地亚里耶卡大学Vanda Jurani? Lisni、Stipan Jonji等研究人员合作发现卵巢的病毒感染可危及怀孕，并揭示保护生育力的先天免疫机制。这一研究成果于2021年5月19日在线发表在国际学术期刊《免疫》上。

研究人员采用鼠巨细胞病毒（CMV）作为模型来研究病毒感染对妊娠结局和生育能力的影响。即使怀孕的小鼠成功地控制了CMV感染，研究人员仍观察到卵巢中黄体（CL）细胞的高度选择性强烈感染。高感染密度表明CL细胞免疫控制完全失败，导致孕酮功能不全和妊娠流失。大量的缝隙连接、没有脉管系统、强烈的I型干扰素（IFN）反应以及先天免疫细胞的相互作用完全保护了卵巢滤泡免受病毒感染。这项工作提供了有关CMV感染对妊娠流产的影响以及保护生育力机制的基本见解。

据悉，怀孕期间的病毒感染是造成不良后果和出生缺陷的重要原因，人们对其潜在的机制了解甚少。其中，CMV感染是人类最常见的子宫内感染，据推测会导致早期妊娠流产。

附：英文原文

Title: Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility

Author: Jelena Tomac, Marija Mazor, Berislav Lisni, Mijo Golemac, Daria Kvetak, Marina Brali, Lidija Bili Zulle, Melanie M. Brinkmann, Lars Dlken, Line S. Reinert, Soren R. Paludan, Astrid Krmpoti, Stipan Jonji, Vanda Jurani Lisni

Issue&Volume: 2021-05-19

Abstract: Viral infections during pregnancy are a considerable cause of adverse outcomes andbirth defects, and the underlying mechanisms are poorly understood. Among those, cytomegalovirus(CMV) infection stands out as the most common intrauterine infection in humans, putativelycausing early pregnancy loss. We employed murine CMV as a model to study the consequencesof viral infection on pregnancy outcome and fertility maintenance. Even though pregnantmice successfully controlled CMV infection, we observed highly selective, strong infectionof corpus luteum (CL) cells in their ovaries. High infection densities indicated complete failureof immune control in CL cells, resulting in progesterone insufficiency and pregnancyloss. An abundance of gap junctions, absence of vasculature, strong type I interferon(IFN) responses, and interaction of innate immune cells fully protected the ovarianfollicles from viral infection. Our work provides fundamental insights into the effectof CMV infection on pregnancy loss and mechanisms protecting fertility.

DOI: 10.1016/j.immuni.2021.04.020

Source: https://www.cell.com/immunity/fulltext/S1074-7613(21)00182-5