南京师范大学万密密团队设计了两性离子基硫化氢纳米马达通过破坏肿瘤代谢共生，诱导肿瘤细胞多发性酸中毒。相关研究成果于2021年4月29日发表于国际一流学术期刊《德国应用化学》。

破坏肿瘤代谢共生是一种非常吸引力的肿瘤治疗方法，该方法以肿瘤细胞为靶点，对正常细胞伤害小。然而，单一的介入策略和药物在肿瘤组织中的渗透性差，治疗效果有限。

该文根据人体反应的基本原理，提出了一种零废物两性离子基硫化氢（H2S）驱动的纳米马达。一元羧酸转运体抑制剂α‐氰基-4-羟基肉桂酸(α‐CHCA），纳米马达可以在肿瘤微环境中运动，通过运动效应与H2S和α‐CHCA驱动力的协同作用，诱导肿瘤细胞发生多重酸中毒，抑制肿瘤生长。鉴于这种纳米马达的底物和驱动气体具有良好的生物安全性，以及目前可在肿瘤微环境中移动的纳米马达种类有限，该纳米马达可能为癌症治疗的主动给药系统提供有竞争力的候选物。

附：英文原文

Title: Zwitterion‐based hydrogen sulfide nanomotors induce multiple acidosis in tumor cells by destroying tumor metabolic symbiosis

Author: Mimi Wan, Zhiyong Liu, Ting Li, Huan Chen, Qi Wang, Tiantian Chen, Yingfang Tao, Chun Mao

Issue&Volume: 2021-04-29

Abstract: Destruction of tumor metabolism symbiosis is an attractive cancer treatment method which targets tumor cells with little harm to normal cells. Yet, a single intervention strategy and poor penetration of the drug in tumor tissue result in limited effect. Herein, we propose a zero‐waste zwitterion‐based hydrogen sulfide (H  2  S)‐driven nanomotor based on the basic principle of reaction in human body. When loaded with monocarboxylic acid transporter inhibitor α‐cyano‐4‐hydroxycinnamic acid (α‐CHCA), the nanomotor can move in tumor microenvironment and induce multiple acidosis of tumor cells and inhibit tumor growth through the synergistic effect of motion effect, driving force H  2  S and α‐CHCA. Given the good biosafety of the substrate and driving gas of this kind of nanomotor, as well as the limited variety of nanomotors currently available to move in the tumor microenvironment, this kind of nanomotor may provide a competitive candidate for the active drug delivery system of cancer treatment.

DOI: 10.1002/anie.202104304

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202104304