当前位置:科学网首页 > 小柯机器人 >详情
切尔诺贝利事故产生的电离辐射不会对后代产生影响
作者:小柯机器人 发布时间:2021/4/25 13:43:51

美国国家癌症研究所Stephen J. Chanock团队在研究中取得进展。他们揭示切尔诺贝利事故产生的电离辐射不会对后代产生影响。这一研究成果发表在2021年4月23日出版的国际学术期刊《科学》杂志上。

他们研究了清洁工人所生的孩子或事故后接触职业和环境电离辐射下所生孩子是否带有更多的新生系突变(DNM)。与以前的研究相比,对130名儿童(1987年至2002年出生)及其父母进行的全基因组测序未显示DNM的发生率、分布或类型有所增加。

无论累积接触离子辐射的先孕性腺性父亲(平均= 365 mGy,范围= 0-4,080 mGy)或母亲(平均= 19 mGy,范围= 0-550 mGy),他们均未发现总DNM升高,并就此得出结论:在这一研究范围内,缺乏对人类种系DNM产生实质性影响的证据,这表明对后代健康的影响极小。

附:英文原文

Title: Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident

Author: Meredith Yeager, Mitchell J. Machiela, Prachi Kothiyal, Michael Dean, Clara Bodelon, Shalabh Suman, Mingyi Wang, Lisa Mirabello, Chase W. Nelson, Weiyin Zhou, Cameron Palmer, Bari Ballew, Leandro M. Colli, Neal D. Freedman, Casey Dagnall, Amy Hutchinson, Vibha Vij, Yosi Maruvka, Maureen Hatch, Iryna Illienko, Yuri Belayev, Nori Nakamura, Vadim Chumak, Elena Bakhanova, David Belyi, Victor Kryuchkov, Ivan Golovanov, Natalia Gudzenko, Elizabeth K. Cahoon, Paul Albert, Vladimir Drozdovitch, Mark P. Little, Kiyohiko Mabuchi, Chip Stewart, Gad Getz, Dimitry Bazyka, Amy Berrington de Gonzalez, Stephen J. Chanock

Issue&Volume: 2021/04/22

Abstract: Effects of radiation exposure from the Chernobyl nuclear accident remain a topic of interest. We investigated whether children born to parents employed as cleanup workers or exposed to occupational and environmental ionizing radiation post-accident were born with more germline de novo mutations (DNMs). Whole-genome sequencing of 130 children (born 1987-2002) and their parents did not reveal an increase in the rates, distributions, or types of DNMs versus previous studies. We find no elevation in total DNMs regardless of cumulative preconception gonadal paternal (mean = 365 mGy, range = 0-4,080 mGy) or maternal (mean = 19 mGy, range = 0-550 mGy) exposure to ionizing radiation and conclude over this exposure range, evidence is lacking for a substantial effect on germline DNMs in humans, suggesting minimal impact on health of subsequent generations.

DOI: 10.1126/science.abg2365

Source: https://science.sciencemag.org/content/early/2021/04/21/science.abg2365

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037