复旦大学张凡团队开发了一种有前途的用于肽介导的肾功能障碍长期监测的NIR‐II荧光传感器。相关研究成果发表在2021年4月20日出版的《德国应用化学》。

肾脏疾病在早期通常“沉默的” ，但后期会导致严重的肾衰竭。在肾脏中快速分布和长期滞留的生物成像探针的研制对肾脏疾病的准确诊断具有重要意义。

该文阐述了一个简便的肽介导的传递和第二近红外窗口(NIR‐II)荧光的长期离累（>48h）策略。结果表明，与高极性肽结合后，肝脏清除的有机分子和快速肾脏清除的超小纳米粒都能保留在肾脏中。此外，ROS‐反应性激活双侧NIR‐II传感器是基于肾脏靶向肽设计的，这使得两者在体内的时间都很长，从而能够长期肾脏监测和体外尿液检测。肽基传感器检测早期肾损伤并报告肾功能不全进展的能力对于化疗方案的优化和药物治疗期间及时的肾保护干预尤为重要。

附：英文原文

Title: A Promising NIR‐II Fluorescent Sensor for Peptide‐Mediated Long‐term Monitoring of Kidney Dysfunction

Author: Fan Zhang, Ying Chen, Peng Pei, Zuhai Lei, Xin Zhang, Dongrui Yin

Issue&Volume: 2021-04-20

Abstract: Kidney disease is usually “silent” at the early stage but can lead to severe kidney failure later on. The development of bioimaging probes with rapid distribution and long‐term retention in the kidney is significant for precisely diagnosing of renal diseases. Here, a feasible strategy of peptide mediated delivering and long‐term accumulating (>48 h) of second near‐infrared window (NIR‐II) fluorophores into kidney is demonstrated. It is shown that both the hepatic cleared organic molecules and fast renal cleared ultrasmall nanoparticles can be retained in the kidney after conjugated to the peptide with high polarity. Moreover, a ROS‐responsive activatable bilateral NIR‐II sensor was designed based on the kidney targeting peptide, which enables both in vivo long‐term kidney monitoring and in vitro urine detection. The capability of peptide‐based sensor to detect early kidney injury and report on kidney dysfunctional progression is particularly crucial for chemotherapy regimen optimization and timely renoprotective intervention during medications.

DOI: 10.1002/anie.202103071

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202103071