美国斯坦福大学Scott D. Boyd研究组取得最新进展。他们发现冠状病毒和其他病原体共享的B细胞记忆在人类年龄组和组织中有所不同。 该研究于2021年4月12日年发表于国际一流学术期刊《科学》杂志上。

他们评估了儿童和成人血液个体和已故器官供体组织之间共享的相似序列的共同抗原特异性抗体基因。不同的病原体的B细胞记忆不同。多糖抗原特异性克隆不是脾脏独有的。个体比血液具有更高的克隆频率和更大的淋巴组织类别转换，而儿童血液具有丰富的类别转换共同克隆。

与已报道的血清学一致，大流行前儿童的类转换趋同克隆为SARS-CoV-2，与其他冠状病毒的交叉反应性较弱，而成人血液或组织中几乎没有此类克隆。结果突出了幼儿B细胞克隆扩增和交叉反应性对未来新型病原体反应的突出作用。

据了解，疫苗接种和感染会促进B细胞的形成、组织分布和克隆进化，而B细胞编码体液免疫记忆。

附：英文原文

Title: Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

Author: Fan Yang, Sandra C. A. Nielsen, Ramona A. Hoh, Katharina Rltgen, Oliver Fabian Wirz, Emily Haraguchi, Grace H. Jean, Ji-Yeun Lee, Tho D. Pham, Katherine J. L. Jackson, Krishna M. Roskin, Yi Liu, Khoa Nguyen, Robert S. Ohgami, Eleanor M. Osborne, Kari C. Nadeau, Claus U. Niemann, Julie Parsonnet, Scott D. Boyd

Issue&Volume: 2021/04/12

Abstract: Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated convergent antigen-specific antibody genes of similar sequences shared between individuals in pediatric and adult blood, and deceased organ donor tissues. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class-switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, pre-pandemic children had class-switched convergent clones to SARS-CoV-2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. The results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.

DOI: 10.1126/science.abf6648

Source: https://science.sciencemag.org/content/early/2021/04/09/science.abf6648