中国科学技术大学刘扬中团队通过综合级联反应使刺激响应性锰单原子纳米酶用于肿瘤治疗。相关研究成果发表在2021年2月05日出版的《德国应用化学》。

单原子酶（SAE）是一种新型纳米酶，具有优异的催化活性。SAE通过改变细胞氧化还原平衡在肿瘤治疗中具有很大的潜力。

该研究中，研究人员通过在中空的沸石-咪唑盐框架中单原子锰与氮原子的配位构建了一个聚乙二醇化的锰基SAE（Mn/PSAE）。Mn/PSAE通过类Fenton反应催化细胞H₂ O₂转化为–OH；它还促进H₂O^₂分解为O₂，并通过类氧化酶活性持续催化O₂转化为细胞毒性–O2。Mn/PSAE的催化活性在弱酸性肿瘤环境中更为显著，因此，这些级联反应能够产生足够的活性氧（ROS）并有效地杀死肿瘤细胞。

此外，非晶态碳突出的光热转换特性可用于光热疗法。因此，Mn/PSAE通过肿瘤微环境刺激产生多种ROS和光热活性而显示出显著的治疗效果。

附：英文原文

Title: Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions

Author: Yang Zhu, Wenyu Wang, Junjie Cheng, Chao Zhao, Yi Dai, Manman Liu, Jianing Yu, Chengming Wang, Huijuan Wang, Sicong Wang, Yunteng Qu, Yuen Wu, Yangzhong Liu

Issue&Volume: 05 February 2021

Abstract: Single‐atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary catalytic activity. SAE has recently been demonstrated high potential in tumor therapy by altering cellular redox balance. Here, we constructed a PEGylated manganese‐based SAE (Mn/PSAE) by coordination of single‐atom manganese to nitrogen atoms in hollow zeolitic imidazolate frameworks. Mn/PSAE catalyzes the conversion of cellular H  2  O  2  to –OH through a Fenton‐like reaction; it also promotes the decomposition of H  2  O  2  to O  2  and continuously catalyzes the conversion of O  2  to cytotoxic –O  2  ‐  via  oxidase‐like activity. The catalytic activity of Mn/PSAE is more pronounced in the weak acidic tumor environment; therefore, these cascade reactions enable the sufficient generation of reactive oxygen species (ROS) and effectively kill tumor cells. In addition, the prominent photo‐thermal conversion property of the amorphous carbon can be utilized for photothermal therapy. Hence, Mn/PSAE exhibits significant therapeutic efficacy through tumor microenvironment stimulated generation of multiple ROS and photothermal activity.

DOI: 10.1002/anie.202017152

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202017152