中南大学黄勇团队报道了具有前所未有分子结构的铜（II）金属载体，白垩磷霉素的表征。相关研究成果发表在2021年12月1日出版的《美国化学会杂志》。

金属通过与小分子、蛋白质和核酸的配位在生命中发挥重要作用。虽然铜离子在许多蛋白质和甲基肌蛋白中的配位是已知的，但是铜（II）在天然产物中的配位化学及其生物学功能仍然没有得到充分的研究。

该文中，研究人员报告了从链霉菌属CB00271中发现的一种与铜（II）结合的天然产物白垩磷霉素（CHM，1），其特征是双齿二氮唑盐和共轭1H吡咯1-氧化物-恶唑啉的不对称方形配位系统。1的结构可能激发铜（II）螯合剂的合成，用于抗神经退行性疾病或基于铜（II）的抗肿瘤治疗。

附：英文原文

Title: Characterization of Chalkophomycin, a Copper(II) Metallophore with an Unprecedented Molecular Architecture

Author: Bang Gong, Enhe Bai, Xueqiong Feng, Liwei Yi, Yeji Wang, Xin Chen, Xiangcheng Zhu, Yanwen Duan, Yong Huang

Issue&Volume: December 1, 2021

Abstract: Metals play essential roles in life by coordination with small molecules, proteins, and nucleic acids. Although the coordination of copper ions in many proteins and methanobactins is known, the coordination chemistry of Cu(II) in natural products and their biological functions remain underexplored. Herein, we report the discovery of a Cu(II)-binding natural product, chalkophomycin (CHM, 1), from Streptomyces sp. CB00271, featuring an asymmetric square-coordination system of a bidentate diazeniumdiolate and a conjugated 1H-pyrrole 1-oxide-oxazoline. The structure of 1 may inspire the synthesis of Cu(II) chelators against neurodegenerative diseases or Cu(II)-based antitumor therapeutics.

DOI: 10.1021/jacs.1c09311

Source: https://pubs.acs.org/doi/10.1021/jacs.1c09311