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生物系统中的条件活化光氧化还原催化
作者:小柯机器人 发布时间:2021/12/31 15:48:08

大连理工大学彭孝军团队报道了生物系统中的条件活化光氧化还原催化。相关研究成果发表在2021年12月28日出版的《美国化学会杂志》。

光氧化还原催化化学的转化效应激发了新的机会,使人们能够以其他方式不可能的方式探寻自然,并在治疗和诊断中揭示新的生物技术。然而,人工光催化在生命系统中的应用仍然具有挑战性,受到光催化剂毒性的非目标风险和安全问题的困扰。

该文中,研究人员提出了一种吸引人的方法,即条件可激活光催化(ConAPC),作为概念设计的证明,设计了第一种基于经典自焚化学的ConAPC结构(Se-NO2),其中,固有的光催化性能可以暂时保持不变,而物种仅在肿瘤部位通过感应特定的生物标记物而变得活跃。该掩蔽策略能够在体外和体内对光响应性进行时空控制。特别是,对于ConAPC设计,确定了一种新的生物良性无金属光催化剂(Se-NH2),该催化剂能够启动NIR光催化,以操纵O2独立作用机制中的细胞电子池。

通过该独特的策略,在小鼠模型中获得有效的肿瘤特异性靶向光催化根除(TGI:95%)。令人印象深刻的是,还实现了诸如高分辨率肿瘤识别(SBR:33.6)和优异的生物相容性和安全性等有利特性。

因此,该工作为化学家利用人工光催化反应发展简易智能光催化疗法提供了新的可能性。

附:英文原文

Title: Conditionally Activatable Photoredox Catalysis in Living Systems

Author: Mingle Li, Kalayou Hiluf Gebremedhin, Dandan Ma, Zhongji Pu, Tao Xiong, Yunjie Xu, Jong Seung Kim, Xiaojun Peng

Issue&Volume: December 28, 2021

Abstract: The transformational effect of photoredox catalytic chemistries has inspired new opportunities, enabling us to interrogate nature in ways that are not possible otherwise and to unveil new biotechnologies in therapy and diagnosis. However, the deployment of artificial photoredox catalysis in living systems remains challenging, mired by the off-target risk and safety concerns of photocatalyst toxicity. Here, we present an appealing approach, namely conditionally activatable photoredox catalysis (ConAPC), and as a proof of concept design the first ConAPC architecture (Se-NO2) based upon classic self-immolative chemistry, in which the inherent photocatalytic properties can be temporarily caged while the species becomes active only at the tumor sites via sensing to specific biomarkers. Such a masking strategy allows a spatial–temporal control of photoresponsivity in vitro and in vivo. In particular, for ConAPC design, a new biologically benign metal-free photocatalyst (Se-NH2), which is able to initiate NIR photoredox catalysis to manipulate the cellular electron pool in an O2-independent mechanism of action, is identified. With this unique strategy, potent tumor-specific targeting photocatalytic eradication (TGI: 95%) is obtained in a mouse model. Impressively, favorable features such as high-resolution tumor recognition (SBR: 33.6) and excellent biocompatibility and safety are also achieved. This work therefore offers a new possibility for chemists to leverage artificial photocatalytic reactions toward the development of facile and intelligent photocatalytic theranostics.

DOI: 10.1021/jacs.1c07372

Source: https://pubs.acs.org/doi/10.1021/jacs.1c07372

 

期刊信息

JACS:《美国化学会志》,创刊于1879年。隶属于美国化学会,最新IF:14.612
官方网址:https://pubs.acs.org/journal/jacsat
投稿链接:https://acsparagonplus.acs.org/psweb/loginForm?code=1000