当前位置:科学网首页 > 小柯机器人 >详情
科学家发现通过循环使用细胞内Dpp蛋白来调节形态梯度缩放的机制
作者:小柯机器人 发布时间:2021/12/26 14:34:00

瑞士日内瓦大学Marcos Gonzalez-Gaitan ,Maria Romanova Michailidi 和 德国马普复杂系统物理研究所 Frank Jülicher 共同合作取得重要工作进展。他们发现通过循环使用细胞内Dpp蛋白来调节形态梯度缩放的机制。该项研究成果于2021年12月22日在线发表在《自然》杂志上。

在这里,研究人员聚焦于果蝇翅盘的 Dpp 分子梯度,揭示了形态梯度缩放背后的细胞生物学基础。从小翅盘到大翅盘,Dpp 梯度的调节是通过增加内化的Dpp分子对Dpp转运的贡献来实现的:为了扩大梯度,内吞的 Dpp 分子被重新释放到细胞外。在组织生长过程中,细胞外因子 Pentagone 通过逐步调节 Dpp 的结合效率来操控 Dpp 分子在细胞外的释放,从而推动细胞缩放。因此,对于某些形态源来说,进化可能通过内吞作用来调节梯度的范围和尺度,从而使形状和模式适应不同物种中不同大小的器官。

据介绍,形态发生梯度是在发育组织中建立形态学模式的基础。在发育过程中,梯度缩放以保持与生长器官大小成正比。在生物体中,缩放是一种通用的调节模式,但它的具体机制目前还不清楚。

附:英文原文

Title: Morphogen gradient scaling by recycling of intracellular Dpp

Author: Michailidi, Maria Romanova, Hadjivasiliou, Zena, Aguilar-Hidalgo, Daniel, Basagiannis, Dimitris, Seum, Carole, Dubois, Marine, Jlicher, Frank, Gonzalez-Gaitan, Marcos

Issue&Volume: 2021-12-22

Abstract: Morphogen gradients are fundamental to establish morphological patterns in developing tissues1. During development, gradients scale to remain proportional to the size of growing organs2,3. Scaling is a universal gear adjusting patterns to size in living organisms3–8, yet its mechanisms remain unclear. Here, focusing on the Dpp gradient in the Drosophila wing disc, we unravel a cell biological basis behind scaling. From small to large discs, scaling of the Dpp gradient is achieved by increasing the contribution of the internalized Dpp molecules to Dpp transport: to expand the gradient, endocytosed molecules are re-exocytosed to spread extracellularly. To regulate the contribution of endocytosed Dpp to the spreading extracellular pool during tissue growth, it is the Dpp binding rates that are progressively modulated by the extracellular factor Pentagone, driving scaling. Thus, for some morphogens, evolution may act on endocytic trafficking to regulate the range of the gradient and its scaling, which could allow adaptation of shape and pattern to different sizes of organs in different species.

DOI: 10.1038/s41586-021-04346-w

Source: https://www.nature.com/articles/s41586-021-04346-w

期刊信息

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html