近日，法国PSL研究大学Ana-Maria Lennon-Duménil及其小组发现，肠道树突状细胞的上皮定植促进其功能多样化。该项研究成果于2021年12月14日在线发表在《免疫》杂志上。

据了解，DC巡视组织并将抗原运送到淋巴结来启动适应性免疫反应。在组织内，树突状细胞构成一个复杂的细胞群，由不同的亚群组成，可以表现出不同的激活状态和功能。组织特异性的线索如何协调DC的多样化仍然难以捉摸。

附：英文原文

Title: Epithelial colonization by gut dendritic cells promotes their functional diversification

Author: Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil

Issue&Volume: 2021-12-14

Abstract: Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes to initiate adaptive immune responses. Within tissues, DCs constitute a complex cell population composed of distinct subsets that can exhibit different activation states and functions. How tissue-specific cues orchestrate DC diversification remains elusive. Here, we show that the small intestine included two pools of cDC2s originating from common pre-DC precursors: (1) lamina propria (LP) CD103+CD11b+ cDC2s that were mature-like proinflammatory cells and (2) intraepithelial cDC2s that exhibited an immature-like phenotype as well as tolerogenic properties. These phenotypes resulted from the action of food-derived retinoic acid (ATRA), which enhanced actomyosin contractility and promoted LP cDC2 transmigration into the epithelium. There, cDC2s were imprinted by environmental cues, including ATRA itself and the mucus component Muc2. Hence, by reaching distinct subtissular niches, DCs can exist as immature and mature cells within the same tissue, revealing an additional mechanism of DC functional diversification.

DOI: 10.1016/j.immuni.2021.11.008

Source: https://www.cell.com/immunity/fulltext/S1074-7613(21)00499-4