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运动可增强记忆力并抑制脑炎
作者:小柯机器人 发布时间:2021/12/11 20:39:53

美国斯坦福大学医学院Tony Wyss-Coray团队发现运动血浆通过凝聚素增强记忆力,并抑制脑部炎症。相关论文于2021年12月8日发表在《自然》杂志上。

他们展示了从喜爱运动的小鼠身上收集“运动血浆”,并将其注入久坐不动的小鼠体内,可降低基线神经炎症基因表达和实验诱导的脑炎。血浆蛋白质组学分析显示补体级联抑制剂包括凝聚素 (CLU) 的协同增加。静脉注射的 CLU 与脑内皮细胞结合并降低急性脑部炎症小鼠模型和阿尔茨海默病小鼠模型中神经炎症基因的表达。参加结构性运动 6 个月的认知障碍患者的 CLU 血浆水平较高。这些发现证明了抗炎运动因子的存在,这些因子是可转移的,针对脑血管系统并有益于大脑,并且存在于参与运动的人体中。

据了解,体育锻炼通常有益于人类和动物健康的各个方面,减缓认知老化和神经退化。体育锻炼的认知益处与海马体内可塑性增加和炎症减少有关,但对调节这些影响的因素和机制知之甚少。

附:英文原文

Title: Exercise plasma boosts memory and dampens brain inflammation via clusterin

Author: De Miguel, Zurine, Khoury, Nathalie, Betley, Michael J., Lehallier, Benoit, Willoughby, Drew, Olsson, Niclas, Yang, Andrew C., Hahn, Oliver, Lu, Nannan, Vest, Ryan T., Bonanno, Liana N., Yerra, Lakshmi, Zhang, Lichao, Saw, Nay Lui, Fairchild, J. Kaci, Lee, Davis, Zhang, Hui, McAlpine, Patrick L., Contrepois, Kvin, Shamloo, Mehrdad, Elias, Joshua E., Rando, Thomas A., Wyss-Coray, Tony

Issue&Volume: 2021-12-08

Abstract: Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration1. The cognitive benefits of physical exercise are tied to an increased plasticity and reduced inflammation within the hippocampus2,3,4, yet little is known about the factors and mechanisms that mediate these effects. Here we show that ‘runner plasma’, collected from voluntarily running mice and infused into sedentary mice, reduces baseline neuroinflammatory gene expression and experimentally induced brain inflammation. Plasma proteomic analysis revealed a concerted increase in complement cascade inhibitors including clusterin (CLU). Intravenously injected CLU binds to brain endothelial cells and reduces neuroinflammatory gene expression in a mouse model of acute brain inflammation and a mouse model of Alzheimer’s disease. Patients with cognitive impairment who participated in structured exercise for 6 months had higher plasma levels of CLU. These findings demonstrate the existence of anti-inflammatory exercise factors that are transferrable, target the cerebrovasculature and benefit the brain, and are present in humans who engage in exercise.

DOI: 10.1038/s41586-021-04183-x

Source: https://www.nature.com/articles/s41586-021-04183-x

期刊信息

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html