当前位置:科学网首页 > 小柯机器人 >详情
Kr-h1维持不同的阶级特异性神经转录组以响应社会调节的激素
作者:小柯机器人 发布时间:2021/11/7 13:20:41

美国宾夕法尼亚大学Roberto Bonasio、Shelley L. Berger等研究人员合作发现,Kr-h1维持不同的阶级特异性神经转录组以响应社会调节的激素。2021年11月4日,《细胞》杂志在线发表了这项成果。

研究人员表示,行为的可塑性是动物生存的关键。跳镰猛蚁(Harpegnathos saltator)可以根据社会冲突的结果在工蚁和蚁后一样的地位(繁殖蚁)之间转换,为研究不同的行为状态如何在成年大脑中实现提供了机会。

通过在活蚂蚁和蚂蚁神经元培养物中进行社会和分子操作,研究人员表明蜕皮激素和幼年激素驱动着工蚁和繁殖蚁大脑中的分子和功能差异,并将转录抑制因子Kr-h1导向不同的靶标基因。大脑中Kr-h1的耗尽导致"社会上不合适的"基因的去抑制:工蚁中的繁殖蚁基因被上调,而工蚁基因在繁殖蚁中被上调。在表型层面上,Kr-h1的缺失导致了繁殖蚁的工蚁特定行为和工蚁的繁殖蚁特定性状的出现。研究人员的结论是,Kr-h1是一个转录因子,它维持着为响应社会调节激素而建立的不同大脑状态。

附:英文原文

Title: Kr-h1 maintains distinct caste-specific neurotranscriptomes in response to socially regulated hormones

Author: Janko Gospocic, Karl M. Glastad, Lihong Sheng, Emily J. Shields, Shelley L. Berger, Roberto Bonasio

Issue&Volume: 2021-11-04

Abstract: Behavioral plasticity is key to animal survival. Harpegnathos saltator ants can switch between worker and queen-like status (gamergate) depending on the outcome of social conflicts, providing an opportunity to study how distinct behavioral states are achieved in adult brains. Using social and molecular manipulations in live ants and ant neuronal cultures, we show that ecdysone and juvenile hormone drive molecular and functional differences in the brains of workers and gamergates and direct the transcriptional repressor Kr-h1 to different target genes. Depletion of Kr-h1 in the brain caused de-repression of “socially inappropriate” genes: gamergate genes were upregulated in workers, whereas worker genes were upregulated in gamergates. At the phenotypic level, loss of Kr-h1 resulted in the emergence of worker-specific behaviors in gamergates and gamergate-specific traits in workers. We conclude that Kr-h1 is a transcription factor that maintains distinct brain states established in response to socially regulated hormones.

DOI: 10.1016/j.cell.2021.10.006

Source: https://www.cell.com/cell/fulltext/S0092-8674(21)01180-6

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/