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科学家开发出用于局部近红外增强型催化细菌消毒的仿生催化剂
作者:小柯机器人 发布时间:2021/11/30 15:31:04

德国柏林自由大学Rainer Haag课题组开发出用于局部近红外增强型催化细菌消毒的仿生催化剂。相关论文于2021年11月26日在线发表在《德国应用化学》杂志上。

研究人员表示,新的仿生催化剂为对抗多药耐药(MDR)细菌开辟了一个新的时代。它们可以在H2O2等化学物质的存在下通过提高活性氧(ROS)的水平来杀死细菌。然而,ROSs的超短扩散距离限制了它们的杀菌活性。

研究人员提出了一种具有细菌结合能力的纳米钩状仿生催化剂(Ni@Co-NC),它在生理H2O2水平下显示出强大的ROS生成能力。Ni@Co-NC依赖于pH值的性能将其影响限制在生物膜的微环境中,使健康组织不受影响。此外,它可以在近红外激光照射下产生热量,增强其催化性能,同时实现对细菌的热消融。在Ni@Co-NC的协同作用下,细菌的数量下降了>99.99%。更令人惊讶的是,成熟的生物被膜在用Ni@Co-NC处理后没有复发,这表明它在治疗MDR细菌相关感染方面具有巨大的潜力。

附:英文原文

Title: A Nanohook-Equipped Bionanocatalyst for Localized Near-Infrared-Enhanced Catalytic Bacterial Disinfection

Author: Xin Fan, Xizheng Wu, Fan Yang, Lei Wang, Kai Ludwig, Lang Ma, Andrej Trampuz, Chong Cheng, Rainer Haag

Issue&Volume: 2021-11-26

Abstract: Novel bionanocatalysts have opened a new era in fighting multidrug-resistant (MDR) bacteria. They can kill bacteria by elevating the level of reactive oxygen species (ROS) in the presence of chemicals like H2O2. However, ROSs’ ultrashort diffusion distance limit their bactericidal activity. We present a nanohook-equipped bionanocatalyst (Ni@Co-NC) with bacterial binding ability that shows robust ROS-generating capacity under physiological H2O2 levels. The Ni@Co-NC’s pH-dependent performance confines its effects to the biofilm microenvironment, leaving healthy tissue unaffected. Furthermore, it can generate heat upon NIR laser irradiation, enhancing its catalytic performance while achieving heat ablation against bacteria. With the Ni@Co-NC’s synergistic effects, bacterial populations fall by >99.99%. More surprisingly, mature biofilm shows no recurrence after treatment with the Ni@Co-NC, demonstrating its tremendous potential for treating MDR bacterial related infections.

DOI: 10.1002/anie.202113833

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202113833

 

期刊信息

Angewandte Chemie:《德国应用化学》,创刊于1887年。隶属于德国化学会,最新IF:12.959
官方网址:https://onlinelibrary.wiley.com/journal/15213773
投稿链接:https://www.editorialmanager.com/anie/default.aspx