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静脉注射卡介苗后的强大IgM反应与预防猕猴的结核分枝杆菌感染有关
作者:小柯机器人 发布时间:2021/11/26 16:06:58

美国哈佛大学Galit Alter、Sarah Fortune等研究人员合作发现,静脉注射卡介苗后的强大IgM反应与预防猕猴的结核分枝杆菌感染有关。相关论文于2021年11月22日在线发表在《自然—免疫学》杂志上。

研究人员表示,由于对保护结核分枝杆菌(Mtb)的相关因素了解不全面,有效的结核病(TB)疫苗的开发受到影响。卡介苗(BCG)的静脉注射为猕猴提供了几乎完全的结核病保护,但它所引起的抗体反应仍未完全确定。

研究人员发现,与传统的皮内卡介苗给药相比,静脉注射卡介苗在猕猴的血浆和肺部驱动了显著的抗体反应。虽然静脉注射卡介苗广泛地扩大了抗体滴度和功能,但免疫猕猴血浆和肺部的IgM滴度是减少细菌负担的最有力标志之一。在接受减毒株Mtb保护性疫苗接种的猕猴中,IgM也发生富集。最后,一种Mtb特异性IgM单克隆抗体减少了Mtb在体外的生存。总的来说,这些数据强调了IgM反应作为保护结核病的标志和媒介的潜在重要性。

附:英文原文

Title: Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques

Author: Irvine, Edward B., ONeil, Anthony, Darrah, Patricia A., Shin, Sally, Choudhary, Alok, Li, Wenjun, Honnen, William, Mehra, Smriti, Kaushal, Deepak, Gideon, Hannah Priyadarshini, Flynn, JoAnne L., Roederer, Mario, Seder, Robert A., Pinter, Abraham, Fortune, Sarah, Alter, Galit

Issue&Volume: 2021-11-22

Abstract: Development of an effective tuberculosis (TB) vaccine has suffered from an incomplete understanding of the correlates of protection against Mycobacterium tuberculosis (Mtb). Intravenous (i.v.) vaccination with Bacille Calmette–Guérin (BCG) provides nearly complete protection against TB in rhesus macaques, but the antibody response it elicits remains incompletely defined. Here we show that i.v. BCG drives superior antibody responses in the plasma and the lungs of rhesus macaques compared to traditional intradermal BCG administration. While i.v. BCG broadly expands antibody titers and functions, IgM titers in the plasma and lungs of immunized macaques are among the strongest markers of reduced bacterial burden. IgM was also enriched in macaques that received protective vaccination with an attenuated strain of Mtb. Finally, an Mtb-specific IgM monoclonal antibody reduced Mtb survival in vitro. Collectively, these data highlight the potential importance of IgM responses as a marker and mediator of protection against TB.

DOI: 10.1038/s41590-021-01066-1

Source: https://www.nature.com/articles/s41590-021-01066-1

期刊信息

Nature Immunology:《自然—免疫学》,创刊于2000年。隶属于施普林格·自然出版集团,最新IF:23.53
官方网址:https://www.nature.com/ni/
投稿链接:https://mts-ni.nature.com/cgi-bin/main.plex