美国麻省理工学院Stefani Spranger研究小组发现，I型干扰素激活CD11b⁺常规树突细胞来促进保护性抗肿瘤CD8⁺T细胞免疫 。相关论文于2021年11月19日在线发表在《免疫》杂志上。

Title: Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity

Author: Ellen Duong, Tim B. Fessenden, Emi Lutz, Teresa Dinter, Leon Yim, Sarah Blatt, Arjun Bhutkar, Karl Dane Wittrup, Stefani Spranger

Issue&Volume: 2021-11-19

Abstract: Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impactanti-tumor immunity. To delineate the DC states associated with productive anti-tumorT cell immunity, we compared spontaneously regressing and progressing tumors. Tumor-reactiveCD8+ T cell responses in Batf3/ mice lacking type 1 DCs (DC1s) were lost in progressor tumors but preserved in regressortumors. Transcriptional profiling of intra-tumoral DCs within regressor tumors revealedan activation state of CD11b+ conventional DCs (DC2s) characterized by expression of interferon (IFN)-stimulatedgenes (ISGs) (ISG+ DCs). ISG+ DC-activated CD8+ T cells ex vivo comparably to DC1. Unlike cross-presenting DC1, ISG+ DCs acquired and presented intact tumor-derived peptide-major histocompatibilitycomplex class I (MHC class I) complexes. Constitutive type I IFN production by regressortumors drove the ISG+ DC state, and activation of MHC class I-dressed ISG+ DCs by exogenous IFN-β rescued anti-tumor immunity against progressor tumors in Batf3/ mice. The ISG+ DC gene signature is detectable in human tumors. Engaging this functional DC statemay present an approach for the treatment of human disease.

DOI: 10.1016/j.immuni.2021.10.020

Source: https://www.cell.com/immunity/fulltext/S1074-7613(21)00458-1