华中师范大学Yao Sun课题组开发出基于金属环的超分子光敏剂，用于体内成像引导的光动力细菌灭活。相关论文于2021年11月21日在线发表在《德国应用化学》杂志上。

研究人员通过pillar[5]arene修饰的金属环和1-butyl-4-[4-(diphenylamino)styryl]pyridinium之间的主客体相互作用，设计了一种基于铂(II)金属环的超分子光敏剂。受益于这种设计，这种超分子光敏剂具有聚集诱导的发射特性，表现出更好的荧光性能和对细菌的高效光动力灭活（PDI）。

体内研究显示，它显示了对金黄色葡萄球菌感染部位的精确荧光跟踪，并在原位对金黄色葡萄球菌进行图像引导的高效PDI，而没有明显的副作用。这些结果表明，金属环与宿主化学的结合可以为开发强大的生物医学光敏剂提供一个范例。

据介绍，细菌感染是对公共卫生的最大威胁之一。通过非侵入性技术对感染部位进行体内实时监测和有效治疗，仍然是一个挑战。

附：英文原文

Title: Design of a Metallacycle-Based Supramolecular Photosensitizer for In Vivo Image-Guided Photodynamic Inactivation of Bacteria

Author: Yuling Xu, Wei Tuo, Liang Yang, Yan Sun, Chonglu Li, Xiaoqiang Chen, Wenchao Yang, Guangfu Yang, Peter J. Stang, Yao Sun

Issue&Volume: 2021-11-21

Abstract: Bacterial infection is one of the greatest threats to public health. In vivo real-time monitoring and effective treatment of infected sites through non-invasive techniques, remain a challenge. Herein, we designed a Pt(II) metallacycle-based supramolecular photosensitizer through the host–guest interaction between a pillar[5]arene-modified metallacycle and 1-butyl-4-[4-(diphenylamino)styryl]pyridinium. Benefit from this design, such supramolecular photosensitizer, with aggregation-induced emission properties, demonstrated improved fluorescence performance and efficient photodynamic inactivation (PDI) of bacteria. In vivo studies revealed that it displayed precise fluorescence tracking of  S. aureus  -infected sites, and in situ performed image-guided efficient PDI of  S. aureus  without noticeable side effects. These results demonstrated that metallacycle combined with host-guest chemistry could provide a paradigm for the development of powerful photosensitizers for biomedicine.

DOI: 10.1002/anie.202110048

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202110048