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植物多酚阳离子表面活性剂六方柱互穿微球的组装
作者:小柯机器人 发布时间:2021/11/20 22:07:59

中国科学院化学研究所王毅琳团队报道了植物多酚阳离子表面活性剂六方柱互穿微球的组装及其作为抗菌分子库的应用。相关研究成果于2021年11月17日发表在《德国应用化学》。

微生物感染已成为人类健康的一大威胁,直接接触被病原微生物污染的表面是主要风险之一。开发长效抗菌材料成为迫切需要。

该文采用植物没食子酸与季铵盐表面活性剂非共价组装的方法制备了一种六角柱互穿微球。与传统抗菌剂的一次性爆发式释放不同,HCIS就像一个“抗菌分子库”,以多级方式释放抗菌成分,从而产生持久的抗菌性能。HCISs具有较强的疏水性和粘附性,适用于各种基质,具有抗水洗性能,即使使用10个周期,体外抗菌效率也较高(>99%)。

同时,HCISs对细菌和真菌具有广谱抗菌活性,与哺乳动物细胞具有良好的生物相容性。该低成本和便携式长效抗菌剂满足了公共场所日益增长的抗感染需求。

附:英文原文

Title: Assembly of Hexagonal Column Interpenetrated Spheres from Plant Polyphenol/Cationic Surfactants and Their Application as Antimicrobial Molecular Banks

Author: Yutan Shen, Shikun Li, Ruilian Qi, Chunxian Wu, Ming Yang, Jie Wang, Zhuojun Cai, Kaiang Liu, Jiling Yue, Bo Guan, Yuchun Han, Shu Wang, Yilin Wang

Issue&Volume: 2021-11-17

Abstract: Microbial infections has become a great threat to human health and one of the main risks arises from direct contact with the surfaces contaminated by pathogenic microbes. Developing long-lasting antimicrobial materials becomes an urgent need. Herein, a kind of hexagonal column interpenetrated spheres (HCISs) are fabricated by non-covalent assembly of plant gallic acid with quaternary ammonium surfactants. Different from one-time burst release of conventional antimicrobial agents, the HCIS acts like a “antimicrobial molecular bank” and releases the antimicrobial ingredients in a multistage way, leading to long-lasting antimicrobial performance. Taking advantage of strong hydrophobicity and adhesion, HCISs are applicable to various substrates and endowed with anti-water washing property, thus showing high  in vitro  antimicrobial efficiency ( > 99 %) even after being used for 10 cycles. Meanwhile, HCISs exhibit broad-spectrum antimicrobial activity against bacteria and fungi, and have good biocompatibility with mammalian cells. Such a low-cost and portable long-lasting antimicrobial agent meets the growing anti-infection demand in public spaces.

DOI: 10.1002/anie.202110938

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202110938

期刊信息

Angewandte Chemie:《德国应用化学》,创刊于1887年。隶属于德国化学会,最新IF:12.959
官方网址:https://onlinelibrary.wiley.com/journal/15213773
投稿链接:https://www.editorialmanager.com/anie/default.aspx