瑞典隆德大学Karin Schillén团队报道了超分子螺旋凝聚。相关研究成果于2021年11月10日发表在《德国应用化学》。

DNA螺旋凝聚成六边形排列的束和圆环代表了生物大分子在纳米尺度上功能组织的一个有趣例子。

缩合模型是基于DNA独特的聚电解质特性，但该文中，研究人员可以通过手性小分子的超分子螺旋获得类似DNA的缩合，从而证明这是一种更普遍的现象。研究人员发现胆盐脱氧胆酸钠在与带相反电荷的均聚物或嵌段共聚物的聚电解质相互作用时可以形成超分子螺旋。在更高的阶数下，可以实现螺旋的受控六边形排列，形成类似DNA的束和圆环。

该结果揭示了共价和超分子非共价螺旋聚电解质之间未知的相似性，激发了构建超分子生物大分子的远见卓识。作为药物纳米载体，聚合物BS超结构将在分子和超分子水平上获得复杂的手性，其对纳米载体辅助药物效率的影响是一个尚未探索的迷人问题。

附：英文原文

Title: Condensed Supramolecular Helices: The Twisted Sisters of DNA

Author: Guanqun Du, Domagoj Beli&#x, Alessandra Del Giudice, Viveka Alfredsson, Anna M. Carnerup, Kaizheng Zhu, Bo Nystr, Yilin Wang, Luciano Galantini, Karin Schill

Issue&Volume: 2021-11-10

Abstract: Condensation of DNA helices into hexagonally packed bundles and toroids represents an intriguing example of functional organization of biological macromolecules at the nanoscale. The condensation models are based on the unique polyelectrolyte features of DNA, however here we could reproduce a DNA-like condensation with supramolecular helices of small chiral molecules, thereby demonstrating that it is a more general phenomenon. We show that bile salt sodium deoxycholate can form supramolecular helices upon interaction with oppositely charged polyelectrolytes of homopolymer or block copolymers. At higher order, a controlled hexagonal packing of the helices into DNA-like bundles and toroids could be accomplished. The results disclose unknown similarities between covalent and supramolecular non-covalent helical polyelectrolytes, which inspire visionary ideas of constructing supramolecular versions of biological macromolecules. As drug nanocarriers the polymer-BS superstructures would get advantage of a complex chirality at molecular and supramolecular levels, whose effect on the nanocarrier assisted drug efficiency is a still unexplored fascinating issue.

DOI: 10.1002/anie.202113279

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202113279