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研究总结髓鞘在神经回路可塑性中的功能
作者:小柯机器人 发布时间:2021/10/10 22:47:16

冰岛大学Ragnhildur Thóra Káradóttir研究小组总结髓鞘在神经回路可塑性中的功能。2021年10月7日,《科学》杂志在线发表了这项成果。

大脑对不断变化的环境做出反应,使有机体能够学习并相应地改变行为。了解这种可塑性基础的工作几乎完全集中在神经元在神经化学突触处发生的功能和基本结构变化上。相对来说,很少有人注意到活动依赖的髓鞘在这种可塑性和控制行为的回路功能输出中的参与。

传统上认为髓鞘是轴突被动绝缘体的观点正在转变为髓鞘的终身变化,由神经元活动和经验来调节。研究人员回顾了髓鞘可塑性在加强控制学习和行为的回路功能方面所起作用的新证据。

附:英文原文

Title: Myelin: A gatekeeper of activity-dependent circuit plasticity

Author: Giulia Bonetto, David Belin, Ragnhildur Thóra Káradóttir

Issue&Volume: 2021-10-07

Abstract: The brain is responsive to an ever-changing environment, enabling the organism to learn and change behavior accordingly. Efforts to understand the underpinnings of this plasticity have almost exclusively focused on the functional and underlying structural changes that neurons undergo at neurochemical synapses. What has received comparatively little attention is the involvement of activity-dependent myelination in such plasticity and the functional output of circuits controlling behavior. The traditionally held view of myelin as a passive insulator of axons is changing to one of lifelong changes in myelin, modulated by neuronal activity and experience. Here we review the nascent evidence of the functional role of myelin plasticity in strengthening circuit functions that underlie learning and behavior.

DOI: aba6905

Source: https://www.science.org/doi/10.1126/science.aba6905

 

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037