英国惠康基因组园区Fiona M. Watt和Sarah A. Teichmann以及英国盖伊医院园区Fiona M. Watt研究团队合作取得一项新突破。他们发现炎性皮肤病中出现细胞发育程序。相关论文发表在2021年1月22日出版的《科学》杂志上。
他们分析了来自发育中的人类胎儿皮肤，健康的成年皮肤以及患有特应性皮炎和牛皮癣的成年皮肤的超过500,000个单细胞的转录组。他们利用这些数据集比较了发育、体内稳态和疾病的细胞状态。他们的分析显示，在头三个月期间，皮肤中先天免疫细胞的富集以及特应性皮炎和牛皮癣中疾病相关淋巴细胞的克隆扩增。
他们发现并验证了特应性皮炎和牛皮癣病变皮肤中产前血管内皮细胞和巨噬细胞程序的重新出现。 这些数据说明了皮肤免疫的活力，并提供了发现针对炎性皮肤疾病中病理发展程序的机会。
据悉，皮肤通过在胚胎发育早期建立的复杂细胞网络赋予生物物理和免疫保护。
附：英文原文
Title: Developmental cell programs are co-opted in inflammatory skin disease
Author: Gary Reynolds, Peter Vegh, James Fletcher, Elizabeth F. M. Poyner, Emily Stephenson, Issac Goh, Rachel A. Botting, Ni Huang, Bayanne Olabi, Anna Dubois, David Dixon, Kile Green, Daniel Maunder, Justin Engelbert, Mirjana Efremova, Krzysztof Polański, Laura Jardine, Claire Jones, Thomas Ness, Dave Horsfall, Jim McGrath, Christopher Carey, Dorin-Mirel Popescu, Simone Webb, Xiao-nong Wang, Ben Sayer, Jong-Eun Park, Victor A. Negri, Daria Belokhvostova, Magnus D. Lynch, David McDonald, Andrew Filby, Tzachi Hagai, Kerstin B. Meyer, Akhtar Husain, Jonathan Coxhead, Roser Vento-Tormo, Sam Behjati, Steven Lisgo, Alexandra-Chloé Villani, Jaume Bacardit, Philip H. Jones, Edel A. O’Toole, Graham S. Ogg, Neil Rajan, Nick J. Reynolds, Sarah A. Teichmann, Fiona M. Watt
Issue&Volume: 2021/01/22
Abstract: The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis. We leveraged these datasets to compare cell states across development, homeostasis, and disease. Our analysis revealed an enrichment of innate immune cells in skin during the first trimester and clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. We uncovered and validated in situ a reemergence of prenatal vascular endothelial cell and macrophage cellular programs in atopic dermatitis and psoriasis lesional skin. These data illustrate the dynamism of cutaneous immunity and provide opportunities for targeting pathological developmental programs in inflammatory skin diseases.
DOI: 10.1126/science.aba6500
Source: https://science.sciencemag.org/content/371/6527/eaba6500