美国斯坦福大学Jan M. Skotheim小组发现，细胞生长会稀释细胞周期抑制蛋白Rb从而触发细胞分裂。该项研究成果发表在2020年7月24日出版的《科学》杂志上。
Title: Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division
Author: Evgeny Zatulovskiy, Shuyuan Zhang, Daniel F. Berenson, Benjamin R. Topacio, Jan M. Skotheim
Abstract: Cell size is fundamental to cell physiology. For example, cell size determines the spatial scale of organelles and intracellular transport and thereby affects biosynthesis. Although some genes that affect mammalian cell size have been identified, the molecular mechanisms through which cell growth drives cell division have remained elusive. We show that cell growth during the G1 phase of the cell division cycle dilutes the cell cycle inhibitor Retinoblastoma protein (Rb) to trigger division in human cells. RB overexpression increased cell size and G1 duration, whereas RB deletion decreased cell size and removed the inverse correlation between cell size at birth and the duration of the G1 phase. Thus, Rb dilution through cell growth in G1 provides one of the long-sought molecular mechanisms that promotes cell size homeostasis.