近日，美国普林斯顿大学Mohamed S. Donia及其课题组绘制了人体肠微生物组对药物代谢的个性化图谱。相关论文于2020年6月10日在线发表在《细胞》杂志上。

Title: Personalized Mapping of Drug Metabolism by the Human Gut Microbiome

Author: Bahar Javdan, Jaime G. Lopez, Pranatchareeya Chankhamjon, Ying-Chiang J. Lee, Raphaella Hull, Qihao Wu, Xiaojuan Wang, Seema Chatterjee, Mohamed S. Donia

Issue&Volume: 2020-06-10

Abstract: The human gut microbiome harbors hundreds of bacterial species with diverse biochemicalcapabilities. Dozens of drugs have been shown to be metabolized by single isolatesfrom the gut microbiome, but the extent of this phenomenon is rarely explored in thecontext of microbial communities. Here, we develop a quantitative experimental frameworkfor mapping the ability of the human gut microbiome to metabolize small molecule drugs:Microbiome-Derived Metabolism (MDM)-Screen. Included are a batch culturing systemfor sustained growth of subject-specific gut microbial communities, an ex vivo drug metabolism screen, and targeted and untargeted functional metagenomic screensto identify microbiome-encoded genes responsible for specific metabolic events. Ourframework identifies novel drug-microbiome interactions that vary between individualsand demonstrates how the gut microbiome might be used in drug development and personalized medicine.

DOI: 10.1016/j.cell.2020.05.001

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30563-8