美国哈佛大学Samir Mitragotri等研究人总结了组织特异性药物递送的靶向策略。相关综述论文于2020年4月2日发表在《细胞》杂志上。
Title: Targeting Strategies for Tissue-Specific Drug Delivery
Author: Zongmin Zhao, Anvay Ukidve, Jayoung Kim, Samir Mitragotri
Issue&Volume: 2020/04/02
Abstract: Off-target effects of systemically administered drugs have been a major hurdle in designing therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to enable site-specific drug delivery holds promise in reducing off-target effects, decreasing unwanted toxicities, and thereby enhancing a drug’s therapeutic efficacy. Over the past three decades, a large body of literature has focused on understanding the biological barriers that hinder tissue-specific drug delivery and strategies to overcome them. These efforts have led to several targeting strategies that modulate drug delivery in both the preclinical and clinical settings, including small molecule-, nucleic acid-, peptide-, antibody-, and cell-based strategies. Here, we discuss key advances and emerging concepts for tissue-specific drug delivery approaches and their clinical translation.
DOI: 10.1016/j.cell.2020.02.001
Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30145-8