美国加州大学旧金山分校Daniel A. Lim团队发现，MLL1蛋白维持神经干细胞位置身份。相关论文于2020年4月3日发表于《科学》杂志。

Title: Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1

Author: Ryan N. Delgado, Benjamin Mansky, Sajad Hamid Ahanger, Changqing Lu, Rebecca E. Andersen, Yali Dou, Arturo Alvarez-Buylla, Daniel A. Lim

Issue&Volume: 2020/04/03

Abstract: Abstract

Neural stem cells (NSCs) in the developing and postnatal brain have distinct positional identities that dictate the types of neurons they generate. Although morphogens initially establish NSC positional identity in the neural tube, it is unclear how such regional differences are maintained as the forebrain grows much larger and more anatomically complex. We found that the maintenance of NSC positional identity in the murine brain requires a mixed-lineage leukemia 1 (Mll1)–dependent epigenetic memory system. After establishment by sonic hedgehog, ventral NSC identity became independent of this morphogen. Even transient MLL1 inhibition caused a durable loss of ventral identity, resulting in the generation of neurons with the characteristics of dorsal NSCs in vivo. Thus, spatial information provided by morphogens can be transitioned to epigenetic mechanisms that maintain regionally distinct developmental programs in the forebrain.

DOI: 10.1126/science.aba5960

Source: https://science.sciencemag.org/content/368/6486/48