美国国立卫生研究院Kareem A. Zaghloul及其研究团队发现在人类记忆检索过程中皮质脉冲序列发生重置。该研究于2020年3月6日发表在《科学》杂志上。

研究人员发现，人类皮层中波纹振荡反映了单个峰值活动的潜在爆发，这些爆发被存储在记忆特定的序列中。尖峰序列在记忆形成过程中反复发生，并在成功的记忆检索过程中重放，并且该重放与内侧颞叶的波纹有关。这些数据证明，人类的情节性记忆是由特定神经活动序列编码的，回忆涉及重置这种活动的时间顺序。

据了解，情节记忆检索被认为依赖于过去经验的重放，但是在情节记忆编码和检索过程中人类单个单元活动如何在时间上排布仍然未知。

附：英文原文

Title: Replay of cortical spiking sequences during human memory retrieval

Author: Alex P. Vaz, John H. Wittig, Sara K. Inati, Kareem A. Zaghloul

Issue&Volume: 2020/03/06

Abstract: AbstractEpisodic memory retrieval is thought to rely on the replay of past experiences, yet it remains unknown how human single-unit activity is temporally organized during episodic memory encoding and retrieval. We found that ripple oscillations in the human cortex reflect underlying bursts of single-unit spiking activity that are organized into memory-specific sequences. Spiking sequences occurred repeatedly during memory formation and were replayed during successful memory retrieval, and this replay was associated with ripples in the medial temporal lobe. Together, these data demonstrate that human episodic memory is encoded by specific sequences of neural activity and that memory recall involves reinstating this temporal order of activity.

DOI: 10.1126/science.aba0672

Source: https://science.sciencemag.org/content/367/6482/1131