美国加州大学旧金山分校Takashi Mikawa研究团队发现，沿中线轴的程序性细胞死亡形成原肠运动的同侧性。这一研究成果2020年1月10日发表在国际学术期刊《科学》上。

据介绍，双侧对称是动物界的主要身体发育计划。整个生命过程中，左侧和右侧的细胞在其同侧均保持分隔，但偶尔会发生变化，如妇产科学和人类疾病所证明。如何制定这个进化上保守的身体计划仍然是一个悬而未决的问题。

附：英文原文

Title: Programmed cell death along the midline axis patterns ipsilaterality in gastrulation

Author: Lisandro Maya-Ramos, Takashi Mikawa

Issue&Volume: 2020/01/10

Abstract: Bilateral symmetry is the predominant body plan in the animal kingdom. Cells on the left and right sides remain compartmentalized on their ipsilateral side throughout life, but with occasional variation, as evidenced by gynandromorphs and human disorders. How this evolutionarily conserved body plan is programmed remains a fundamental yet unanswered question. Here, we show that germ-layer patterning in avian gastrulation is ipsilateral despite cells undergoing highly invasive mesenchymal transformation and cell migration. Contralateral invasion is suppressed by extracellular matrix (ECM) and programmed cell death (PCD) along the embryonic midline. Ipsilateral gastrulation was lost by midline ECM and PCD inhibition but restored with exogenously induced PCD. Our data support ipsilaterality as an integral component of bilaterality and highlight a positive functional role of PCD in development.

DOI: 10.1126/science.aaw2731

Source: https://science.sciencemag.org/content/367/6474/197