细胞的主动迁移对肠上皮细胞的稳态更新至关重要，这一成果由法国巴黎文理研究大学Denis Krndija研究组近期取得。该论文于2019年8月16日发表在国际知名学术期刊《科学》上。

据介绍，稳态更新是上皮组织在成年生命中的标志。肠上皮更新的特征是连续的细胞迁移，这被认为是由来自隐窝的有丝分裂压力所驱动的。但是，这种更新的驱动力平衡仍然不明确。

结合生物物理建模和定量三维组织成像与遗传和物理操作，研究人员揭示了肌动蛋白相关蛋白复合物2/3依赖性主动迁移力的存在，这定量地解释了细胞速度、密度和沿着肠绒毛组织张力的分布情况。细胞进行共同迁移，而很少发生重排，同时展示出双-底侧极性以及前-后极性，其特征在于在迁移方向上定向的富含肌动蛋白的基底突起。研究人员认为主动迁移是肠上皮更新的关键组成部分。

附：英文原文

Title: Active cell migration is critical for steady-state epithelial turnover in the gut

Author: Denis Krndija, Fatima El Marjou, Boris Guirao, Sophie Richon, Olivier Leroy, Yohanns Bellaiche, Edouard Hannezo, Danijela Matic Vignjevic

Issue&Volume:Volume 365 Issue 6454

Abstract: Steady-state turnover is a hallmark of epithelial tissues throughout adult life. Intestinal epithelial turnover is marked by continuous cell migration, which is assumed to be driven by mitotic pressure from the crypts. However, the balance of forces in renewal remains ill-defined. Combining biophysical modeling and quantitative three-dimensional tissue imaging with genetic and physical manipulations, we revealed the existence of an actin-related protein 2/3 complex–dependent active migratory force, which explains quantitatively the profiles of cell speed, density, and tissue tension along the villi. Cells migrate collectively with minimal rearrangements while displaying dual—apicobasal and front-back—polarity characterized by actin-rich basal protrusions oriented in the direction of migration. We propose that active migration is a critical component of gut epithelial turnover.

DOI: 10.1126/science.aau3429

Source:https://science.sciencemag.org/content/365/6454/705