论文标题：A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo

期刊：Nature Communications

作者：Xiaomei Wang, Xing Dai, Cen Shi, Jianmei Wan, Mark A. Silver, Linjuan Zhang, Lanhua Chen, Xuan Yi, Bizheng Chen, Duo Zhang, Kai Yang, Juan Diwu, Jianqiang Wang, Yujie Xu, Ruhong Zhou, Zhifang Chai, Shuao Wang

发表时间：2019/06/25

数字识别码： 10.1038/s41467-019-10276-z

原文链接：https://mp.weixin.qq.com/s/5Qg-Qz0B-9PIEJ24ozeZeQ

微信链接：http://t.cn/Ai0zFTJm

根据本周《自然-通讯》发表的一篇论文A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo，一种化合物可以在小鼠暴露于放射性元素铀之后，去除其骨骼和肾脏内的铀。这项研究结果表明，这种化合物或可用于曾暴露于铀的人类身上；不过这还需要经过进一步的测试。

图1：5LIO-1-Cm-3,2-HOPO 的合成 图源：Wang等

铀是一种重要的核能资源，但是其放射性和化学毒性会对人造成健康风险。经历铀暴露后，约三分之二的铀会通过肾脏从体内排出，但是剩余的则会留在肾脏和骨骼中，这会导致肾损害，增加骨缺损和癌症风险。利用螯合剂有可能能去除被身体吸收的铀，但是现有的螯合剂无法有效去除骨骼中的铀，并且具有高毒性。

中国苏州大学的王殳凹及同事改进了现有的羟基吡啶酮基螯合剂，所得新螯合剂对骨骼中的铀络合物的亲和力有所增强。作者表明，这种螯合剂可以有效去除小鼠肾脏和骨骼中的铀，而且其毒性低于其他螯合剂；此外，口服该螯合剂依然有效。

摘要：Searching for actinide decorporation agents with advantages of high decorporation efficiency, minimal biological toxicity, and high oral efficiency is crucial for nuclear safety and the sustainable development of nuclear energy. Removing actinides deposited in bones after intake is one of the most significant challenges remaining in this field because of the instantaneous formation of highly stable actinide phosphate complexes upon contact with hydroxyapatite. Here we report a hydroxypyridinone-based ligand (5LIO-1-Cm-3,2-HOPO) exhibiting stronger affinity for U(VI) compared with the reported tetradentate hydroxypyridinone ligands. This is further revealed by the first principles calculation analysis on bonding between the ligand and uranium. Both in vitro uranium removal assay and in vivo decorporation experiments with mice show that 5LIO-1-Cm-3,2-HOPO can remove uranium from kidneys and bones with high efficiencies, while the decorporation efficiency is nearly independent of the treatment time. Moreover, this ligand shows a high oral decorporation efficiency, making it attractive for practical applications.

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（来源：科学网）