直播时间：2025年5月9日（周五）20:00-21:30

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北京时间2025年5月9日晚八点，iCANX Talks 第226期邀请到了加州大学洛杉矶分校教授李松作为主讲嘉宾，加州大学圣迭戈分校教授Shu Chien，美国东北大学教授Ning Wang，四川大学教授宋阳，北京大学教授张海霞担任研讨嘉宾，北京大学助理教授胡鸿杰担任主持人。这将是一场汇聚顶尖学者的盛会，共同探讨前沿科技与学术挑战！更多精彩，敬请期待！

【嘉宾介绍】

Song Li

加州大学洛杉矶分校

Mechanical Regulation of Cell Memory

【Abstract】

Cell memory plays a crucial role in determining cell identity and phenotype, and is tightly regulated by the cell’s epigenetic state. Mechanical cues in the microenvironment not only influence gene expression through mechanotransduction—mediated by cell surface receptors and transcription factors—but also modulate chromatin organization and the epigenetic landscape. In this talk, I will highlight the significance of mechanical forces and the mechanical properties of biomaterials in shaping both the physical architecture of chromatin and the chemical modifications of DNA and histones, and discuss their applications in cell engineering. In addition, I will present findings demonstrating how the mechanical presentation of activation signals via artificial antigen-presenting cells can alter T cell subpopulations and induce the formation of T memory stem cells, enhancing the efficacy of chimeric antigen receptor (CAR) T cell therapy for cancer treatment. Finally, I will explore future directions in mechanobiology and mechanomedicine.

细胞记忆在决定细胞身份和表型方面起着至关重要的作用，并且受到细胞表观遗传状态的严格调控。微环境中的机械信号不仅通过由细胞表面受体和转录因子介导的机械转导影响基因表达，还能调节染色质结构和表观遗传格局。在本次演讲中，我将重点阐述机械力以及生物材料的机械特性在塑造染色质的物理结构以及DNA和组蛋白的化学修饰方面的重要性，并探讨它们在细胞工程中的应用。此外，我将展示相关研究成果，这些成果表明通过人工抗原呈递细胞呈现的激活信号的机械作用如何改变T细胞亚群，并诱导记忆干细胞的形成，从而提高嵌合抗原受体（CAR）T细胞疗法在癌症治疗中的疗效。最后，我将探索力学生物学和机械医学未来的发展方向。

【BIOGRAPHY】

Professor Song Li holds a B.S. and M.S. from Peking University and a Ph.D. in Bioengineering from UC San Diego, where he also completed postdoctoral training, working with Dr. Shu Chien. He was a professor of bioengineering at UC Berkeley from 2001 to 2015 and served as Chair of the Bioengineering Department at UCLA from 2016 to 2024. Currently, he serves as the Director of the Bioengineering Institute for California, a member of the Board of Directors of the American Institute of Medical and Biological Engineering (AIMBE), and a member of the Governing Council of the International Academy for Medical and Biological Engineering (IAMBE). Dr. Li's research focuses on cell engineering and mechanobiology, with significant contributions to understanding how biophysical factors regulate stem cell differentiation and cell reprogramming. He has pioneered multidisciplinary approaches to engineering biomaterials, stem cells, and immune cells for tissue regeneration and disease therapy. Dr. Li has published over 200 papers in leading scientific journals, including Nature Materials and Nature Biomedical Engineering, filed 19 patent applications, co-edited three books, and served as Co-Editor-in-Chief for Med-X Journal. Additionally, he has reviewed manuscripts for more than 60 journals, delivered over 200 invited lectures, and participated in review and advisory panels for governmental agencies, private organizations, and universities in more than 10 countries. Dr. Li’s contributions to bioengineering have been widely recognized by many awards and honors. These include the Global Biomaterials Leadership Award from the Chinese Association of Biomaterials, and election as a Fellow of the AIMBE, the Biomedical Engineering Society, and IAMBE.  

李松教授拥有北京大学的学士和硕士学位，以及加州大学圣地亚哥分校的生物工程博士学位，并在该校与钱煦博士共同完成了博士后训练。2001年至2015年，他担任加州大学伯克利分校的生物工程教授；2016年至2024年，他担任加州大学洛杉矶分校生物工程系系主任。目前，他担任加州生物工程研究所所长、美国医学与生物工程院（AIMBE）董事会成员以及国际医学与生物工程院（IAMBE）理事会成员。李教授的研究专注于细胞工程和力学生物学，在理解生物物理因素如何调控干细胞分化和细胞重编程方面做出了重要贡献。他开创了多学科方法，利用生物材料、干细胞和免疫细胞进行组织再生和疾病治疗的工程化研究。李教授在包括《自然·材料》和《自然·生物医学工程》在内的顶尖科学期刊上发表了200多篇论文，申请了19项专利，共同编辑了三本书籍，并担任《Med-X杂志》的共同主编。此外，他还为60多家期刊审阅过稿件，做过200多场特邀报告，并参与了10多个国家的政府机构、私人组织和大学的评审和咨询工作。李教授在生物工程领域的贡献获得了广泛认可，并荣获多项奖项和荣誉，其中包括中国生物材料学会颁发的全球生物材料领导力奖，以及当选为美国医学与生物工程院、生物医学工程学会和国际医学与生物工程院的会士。