直播时间：2025年10月17日（周五）20:00-21:30

直播平台：

科学网APP

https://weibo.com/l/wblive/p/show/1022:2321325222739622625346

（科学网微博直播间链接）

科学网微博

科学网视频号

北京时间2025年10月17日晚八点，iCANX Talks 第249期邀请到了香港中文大学（深圳）教授Chenzhong Li担任主讲嘉宾，西湖大学副教授Sumin Bian、香港中文大学副校长助理教授Zhong (Alan) Li、北京大学教授Haixia Zhang担任研讨嘉宾，北京大学助理教授Mengdi Han担任主持人。

这将是一场汇聚顶尖学者的盛会，共同探讨前沿科技与学术挑战！更多精彩，敬请期待！

【嘉宾介绍】

李晨钟

香港中文大学

Smart Biosensors Integrated Organ/Organoid-on-a-Chip

【Abstract】

Organ/organoid-on-a-chip (OoC) platforms are microengineered devices that replicate the structure and function of specific human organs on a microscale. Biosensors are analytical devices that detect and quantify biological or chemical substances by converting a biological response into an electrical signal. Biosensors can be integrated into the chip or placed in the fluidic channels to measure analytes in real time. They can also be used to detect cellular/tissue responses such as contractility in heart-on-a-chip models or barrier integrity in blood brain barrier (BBB) systems. This real-time feedback is crucial for understanding dynamic biological processes and for making rapid decisions in experimental settings. The integration of biosensors with organ-on-a-chip technology represents a groundbreaking advancement in biomedical engineering, offering transformative potential for drug discovery, disease modeling, and personalized medicine. This interdisciplinary approach combines microfluidics, cell biology, and sensor technology to create miniature, physiologically relevant models of human organs that can be monitored in real time.Future advancements are likely to focus on improving sensor sensitivity and specificity, developing user-friendly platforms, and integrating machine learning algorithms for predictive analytics. The convergence of organ-on-a-chip technology with biosensors, artificial intelligence, and lab-on-a-chip systems could lead to the next generation of personalized diagnostics and therapeutics.

器官芯片（Organ/organoid-on-a-chip, OoC）平台是一类微工程设备，能够在微观尺度上复刻特定人体器官的结构与功能。生物传感器则是一种分析设备，可通过将生物反应转化为电信号，实现对生物或化学物质的检测与定量。生物传感器既可以集成到芯片内部，也能放置在微流通道中，对分析物进行实时监测；此外，它还可用于检测细胞 / 组织反应，例如心脏芯片模型中的收缩能力，或是血脑屏障（blood brain barrier, BBB）系统中的屏障完整性。这种实时反馈对于理解动态生物过程、在实验环境中快速决策至关重要。生物传感器与器官芯片技术的结合，是生物医学工程领域的一项突破性进展，为药物研发、疾病建模和个性化医疗带来了变革性潜力。这种跨学科方法融合了微流控技术、细胞生物学与传感技术，能够构建出微型化且具有生理相关性的人体器官模型，并对其进行实时监测。未来的技术进展可能会聚焦于以下方向：提升传感器的灵敏度与特异性、开发用户友好型平台，以及整合机器学习算法以实现预测分析。器官芯片技术与生物传感器、人工智能及芯片实验室系统的融合，有望催生出新一代个性化诊断与治疗技术。

【BIOGRAPHY】

Prof. Chenzhong Li is the X.Q. Deng Presidential Chair professor of Biomedical Engineering and the Director of the Intelligent Biomedical Devices & Bioelectronics Lab in the Chinese University of Hong Kong (Shenzhen) (CUHKSZ). He is the Co-Editors-in-Chief of the journal Biosensor and Bioelectronics and the Technology and Innovation Journal, the society journal of the National Academy of Inventors. He is the elected fellows of the Canadian Academy of Engineering, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering. Before he joined in CUHKSZ, he was the Research Officer at the Biotechnology Research Institute (Montreal) of Canada National Research Council, the World’s Ahead Professor of Biomedical Engineering at Florida International University, the NSF program director of Biosensing Program, and the Professor of Biomedical Engineering and Biochemistry at Tulane University. His scientific research direction is mainly the research and development of bio-optoelectronics and bio-sensing chips. He has published nearly 210 SCI papers including Nature BME, Nature Nano, Advance Science, JACS, Biosensors Bioelectronics, ACS Nano etc., and is the main inventor of 20 patents. He was the founder and technical director of three start-up companies in China, the United States, and Canada.He has received many awards and honors, includingthe 2014 JSPS Senior Professor Award, the 2016 American Brain Mapping Association Technology Development Pioneer Award, and the 2016 Minority Serving Institution Teacher Award. Cancer Research Award (awarded by the American Association for Cancer Research (AACR)), and the 2019 IEEE Distinguished Lecturer Award..

李晨钟教授是香港中文大学（深圳）生物医学工程学系X.Q. Deng讲座教授，同时担任智能生物医学器件与生物电子学实验室主任。他现任国际学术期刊《Biosensors and Bioelectronics》及《Technology and Innovation》（美国国家发明家科学院会刊）共同主编。他是加拿大工程院院士、美国国家发明家科学院院士、美国医学与生物工程院院士。在加入香港中文大学（深圳）之前，陈教授曾任：加拿大国家研究委员会生物技术研究所（蒙特利尔）研究官；佛罗里达国际大学（Florida International University）生物医学工程“World’s Ahead”讲席教授；美国国家科学基金会（NSF）生物传感项目主任；杜兰大学（Tulane University）生物医学工程与生物化学教授。他的主要科研方向为生物光电子学与生物传感芯片的研究与开发。截至目前，他已在 Nature Biomedical Engineering、Nature Nanotechnology、Advanced Science、JACS、Biosensors and Bioelectronics、ACS Nano 等国际权威期刊发表SCI论文近 210篇，拥有20项专利的主要发明权。陈教授还曾在中国、美国和加拿大创办并担任技术总监的初创企业各一家。他曾获得多项国际荣誉，包括：2014年日本学术振兴会（JSPS）高级教授奖，2016年美国脑图谱协会（American Brain Mapping Association）技术开发先锋奖，2016年美国少数族裔高校教师奖（Minority Serving Institution Teacher Award），美国癌症研究协会（AACR）癌症研究奖，以及2019年IEEE杰出演讲人奖（Distinguished Lecturer Award）。