来源:科学网 发布时间:2024/6/11 16:50:57








北京时间6月11日晚八点,iCANX Youth Talks第五十九期邀请到了韩国科学技术院Kyeongha Kwon,代尔夫特理工大学Alina Rwei,多伦多大学Daniel Franklin三位教授主讲,北卡罗来纳大学教堂山分校Wubin Bai教授担任研讨嘉宾,Mengdi Han担任主持人,期待你一起加入这场知识盛宴。


Kyeongha Kwon


The Role of Wireless Technologies in Shaping Digital Healthcare


Viral pandemics, exemplified by COVID-19, underscore the increasing importance of non-contact, remote patient monitoring via wireless medical devices. These systems collect medical health metrics and vitals, such as blood pressure, heartbeat, respiration rate, hydration levels and various biomarkers of different diseases from the user’s devices. Typically utilizing medical wearables and mobile applications, users transform their smartphones into portable laboratories for advanced diagnostics and continuous disease tracking. In this talk, I will discuss the wireless, flexible devices such as an implantable cardiac monitor, and different non-invasive platforms to improve the digital healthcare system, overcoming spatial-temporal gaps in current healthcare provision.



Kyeongha Kwon (Seoul, 1988) is an Assistant Professor in the School of Electrical Engineering, as well as a joint professor in the Department of Semiconductor Engineering, and the Graduate School of AI Semiconductor at KAIST. Her research interests span a wide range of topics in wireline communication, bioelectronics, and battery management system. She is an active Technical Program Committee (TPC) Member of IEEE International Solid-State Circuits Conference (ISSCC) and IEEE Custom Integrated Circuits Conference (CICC). In 2024, she has served as the Country Representative of Korea for the ISSCC Far-East Region. Since 2023, she has held the position of Kwon Oh-Hyun Endowed Professor, funded by Oh-Hyun Kwon, the former Chairman and CEO of Samsung Electronics.

Kyeongha Kwon(首尔,1988年)是韩国高等科技学院电气工程学院的助理教授,同时也是半导体工程系和人工智能半导体研究生院的联合教授。她的研究兴趣涵盖了有线通信、生物电子学和电池管理系统等多个领域。她是IEEE国际固态电路会议(ISSCC)和IEEE定制集成电路会议(CICC)的活跃技术计划委员会(TPC)成员。2024年,她担任ISSCC远东区韩国的国家代表。自2023年以来,她一直担任由三星电子前董事长兼首席执行官权五铉资助的权五铉特聘教授职位。

Alina Y. Rwei


Shedding light on precision biosensing: from wearable bioelectronics to single-particle detection


Optical-based biosensing platforms have the potential to enhance our insights into personalized, real-time diagnostics. Wearable bioelectronics are essential in the development towards such patient-centered technologies, yet current limitations in biosensing also emphasize the need of understanding the fundamentals of biosensing on a single molecule level. In this talk, I will discuss our efforts in the development of soft, flexible wearable optical-based bioelectronics for the monitoring of cerebral hemodynamics on one of the most fragile patient populations: neonatal and pediatric patients. The discussion will then be followed by our work on an aptamer-based biosensor for the real-time, optical detection of endotoxin, a deadly pyrogen. We demonstrate the regeneration and reusability of the sensor suitable for repeated endotoxin measurement. The single molecule detection mode is enabled by dark field microscopy. These platforms have the potential to advance biomarker detection to safeguard the whole value chain: from healthcare products to the health of our patients for real-time detection and diagnostics.



Dr. Rwei is an assistant professor in TU Delft. She received her undergraduate and Ph.D. degrees at the Massachusetts Institute of Technology (MIT), with her undergraduate degree in Chemical Engineering and Ph.D. degree in Materials Science and Engineering. Her Ph.D. training was conducted under the supervision of Professor Robert Langer at MIT and Professor Daniel Kohane at Harvard Medical School. She then proceeded to a postdoctoral position in Professor John Rogers’ lab at Northwestern University. She was the recipient of the Postdoctoral Fellowship Research Training Award (TL1) from the Clinical and Translational Science Awards

Program by NIH/NCATS. Her postdoctoral work pioneered the development of flexible, wearable biosensors designed to have a miniaturized size and mechanical softness suitable for fragile populations such as neonates and children. As a principle investigator in TU Delft, she aims to work at the interdisciplinary fields of precision medicine and chemical engineering, developing biomedical technologies in sensing and therapy for next-generation medicine. Her experience has yielded publications in high-impact journals including Nature Medicine, Nature Biomedical Engineering,

Proceedings of the National Academy of Sciences (PNAS) and Science Advances.

Dr. Rwei 是代尔夫特理工大学的助理教授,她在麻省理工学院(MIT)获得了本科和博士学位,本科学位是化学工程,博士学位是材料科学与工程。她的博士训练是在麻省理工学院的Robert Langer教授和哈佛医学院的Daniel Kohane教授的指导下进行的。之后,她在西北大学的John Rogers教授的实验室担任博士后职位。她曾获得美国国立卫生研究院/临床与转化科学奖(NIH/NCATS)的博士后研究培训奖(TL1)。她的博士后工作开创了柔性、可穿戴生物传感器的开发,这些传感器设计具有微型尺寸和机械柔软性,适合新生儿和儿童等脆弱人群。作为代尔夫特理工大学的首席研究员,她致力于在精准医疗和化学工程的交叉领域工作,为下一代医学开发生物医学技术,用于传感和治疗。她的经历带来了在高影响力期刊上的发表,包括《自然医学》、《自然生物医学工程》、《美国国家科学院院刊》(PNAS)和《科学进展》。

Daniel Franklin


Wearables for Continuous Hemodynamic Monitoring and Classification


Heart failure occurs in approximately 64 million people annually and is one of the leading causes of death globally. Characterized by periods of stability punctuated with life-threatening spells of instability, patients periodically travel to clinics for cardiac assessments. While vital, these visits incur extensive resources and only provide data during the time of evaluation. Wireless, non-invasive, monitoring devices (i.e. wearables) are gaining popularity with patients and clinicians for providing data in between hospital visits – allowing for improved insight and early, timely intervention. However, many of these devices are still limited to heart rate, pulse oximetry, and activity levels.

Here, we summarize our recent progress towards comprehensive cardiovascular monitoring and status classification by utilizing multiple, custom, time-synchronized wearables. Through wearable spectrometers and pulse arrival time models, we target independent correlates of hemodynamic function that not just estimate blood pressure, but also the regulatory mechanisms by which it is maintained or modulated. When applied to remote patient management, we posit that this will enable clinically actionable insights via the ability to classify and monitor types of heart failure and its progression in remote environments.




Daniel Franklin is an Assistant Professor in the Institute of Biomedical Engineering at the University of Toronto, and the Ted Rogers Chair in Cardiovascular Engineering at the Ted Rogers Centre for Heart Failure. He received his doctorate in Physics at the University of Central Florida studying light-matter interactions and developing experimental optoelectronic technologies. As a Post-Doctoral Fellow at Northwestern University, he worked with Professor John Rogers in the fields of bio-integrated electronics and soft-matter photonics. There, Professor Franklin developed novel bioresorbable materials, laser systems, and flexible wireless implants and wearables for hemodynamic monitoring. Throughout this work, he has won numerous awards including the Baxter Young Investigator Award and the Displaying Futures Award from Merck KGaA, Germany – the world’s largest producer of liquid crystal material. Now, in his new role at University of Toronto, Professor Franklin’s lab combines optics, engineering, and physiology to produce medical technologies for commercial translation, in partnership with industry-leading semiconductor manufacturers.

Daniel Franklin 是多伦多大学生物医学工程研究所的助理教授,同时也是 Ted Rogers 心脏衰竭中心的 Ted Rogers 心血管工程主席。他在中佛罗里达大学获得了物理学博士学位,研究光与物质的相互作用,并开发实验性的光电子技术。作为西北大学的博士后研究员,他与 John Rogers 教授一起在生物集成电子学和软物质光学领域工作。在那里,Franklin 教授开发了新型生物可吸收材料、激光系统以及用于血流动力学监测的柔性无线植入物和可穿戴设备。在这项工作中,他获得了众多奖项,包括巴克斯特青年研究者奖和德国默克公司(全球最大的液晶材料生产商)的 Displaying Futures 奖。

在多伦多大学的新角色中,Franklin 教授的实验室结合光学、工程学和生理学,与行业领先的半导体制造商合作,生产医疗技术以供商业转化。


Mengdi Han



Wubin Bai


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