上海交通大学仇子龙团队揭示从海马CA1到压后皮层的抑制性输入对社交行为的控制。相关论文于2024年1月28日在线发表在《神经科学通报》杂志上。

研究人员揭示了压后皮层的一个亚区（RSA）的神经活动最初被激活，然后在社交接触时迅速被抑制。RSA神经元的这种上升-下降阶段对正常的社会行为至关重要。研究发现，海马CA1区的小清蛋白阳性GABA能神经元向RSA发出抑制性投射。阻断这些CA1-RSA抑制性输入会显著损害社交行为。

值得注意的是，增强CA1-RSA的抑制性输入可以挽救自闭症谱系障碍（ASD）小鼠模型的社交行为缺陷。这项研究提出了社会行为显著性处理的神经机制，并确定了利用神经调节方法干预ASD的潜在目标。

据了解，据报道，在ASD的小鼠和非人灵长类动物模型中，与迷幻药相关的异常神经活动与压后皮层在处理感官信息和空间学习中的作用有关。目前还不清楚压后皮层在调节社会行为中的直接作用。

附：英文原文

Title: Gating of Social Behavior by Inhibitory Inputs from Hippocampal CA1 to Retrosplenial Agranular Cortex

Author: Shi, Yuhan, Yan, Jingjing, Xu, Xiaohong, Qiu, Zilong

Issue&Volume: 2024-01-28

Abstract: The retrosplenial cortex has been implicated in processing sensory information and spatial learning, with abnormal neural activity reported in association with psychedelics and in mouse and non-human primate models of autism spectrum disorders (ASDs). The direct role of the retrosplenial cortex in regulating social behaviors remains unclear. In this work, we reveal that neural activity in the retrosplenial agranular cortex (RSA), a subregion of the retrosplenial cortex, is initially activated, then quickly suppressed upon social contact. This up-down phase of RSA neurons is crucial for normal social behaviors. Parvalbumin-positive GABAergic neurons in the hippocampal CA1 region were found to send inhibitory projections to the RSA. Blocking these CA1-RSA inhibitory inputs significantly impaired social behavior. Notably, enhancing the CA1-RSA inhibitory input rescued the social behavior defects in an ASD mouse model. This work suggests a neural mechanism for the salience processing of social behavior and identifies a potential target for ASD intervention using neural modulation approaches.

DOI: 10.1007/s12264-023-01172-0

Source: https://link.springer.com/article/10.1007/s12264-023-01172-0