研究人员展示了参与平衡细胞重力信号转导的LAZY1-LIKE（LZY）家族蛋白与淀粉体及其近端质膜的联系。这导致了根据重力方向的极性定位。研究人员提出了一种重力感应机制，即LZY向质膜的转位通过传递有关淀粉体位置的信息来发出重力方向的信号。
据了解，生物是在重力作用下演化的，许多生物通过特化细胞中的平衡石感知重力方向。在开花植物中，被称为淀粉体的淀粉积累质体可充当平衡石，促进下游的重力作用。长期以来，重力感应机制一直被认为是一种机械感应过程，通过这一过程，淀粉体将力传递到细胞内结构，但其分子机制尚未阐明。
附：英文原文
Title: Cell polarity linked to gravity sensing is generated by LZY translocation from statoliths to the plasma membrane
Author: Takeshi Nishimura, Shogo Mori, Hiromasa Shikata, Moritaka Nakamura, Yasuko Hashiguchi, Yoshinori Abe, Takuma Hagihara, Hiroshi Y. Yoshikawa, Masatsugu Toyota, Takumi Higaki, Miyo Terao Morita
Issue&Volume: 2023-08-10
Abstract: Organisms have evolved under gravitational force and many sense the direction of gravity via statoliths in specialized cells. In flowering plants, starch-accumulating plastids, known as amyloplasts, act as statoliths to facilitate downstream gravitropism. The gravity sensing mechanism has long been considered a mechanosensing process by which amyloplasts transmit forces to intracellular structures, but the molecular mechanism underlying this has not been elucidated. We show here that LAZY1-LIKE (LZY) family proteins involved in statocyte gravity signaling associate with amyloplasts and its proximal plasma membrane. This results in polar localization according to the direction of gravity. We propose a gravity sensing mechanism by which LZY translocation to the plasma membrane signals the direction of gravity by transmitting information on the position of amyloplasts.
DOI: adh9978
Source: https://www.science.org/doi/full/10.1126/science.adh9978