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种子萌发时的一种朊病毒样蛋白质调节因子经历水合依赖性相分离
作者:小柯机器人 发布时间:2021/7/9 14:34:54

美国卡内基科学研究所Seung Y. Rhee、Aaron D. Gitler等研究人员合作发现,种子萌发时的一种朊病毒样蛋白质调节因子经历水合依赖性相分离。这一研究成果于2021年7月6日在线发表在国际学术期刊《细胞》上。

研究人员鉴定了一种未表征的拟南芥朊病毒样蛋白,并将其命名为FLOE1,它在水合作用时相分离,并使胚胎能够感知水分压力。研究人员证明FLOE1浓缩物的生物物理状态在体内调节其在不利环境下抑制种子萌发的生物学功能。研究人员发现FLOE1表达和相分离的基因内、种内和种间自然变异,并表明基因内变异与自然种群的适应性发芽策略有关。这种分子、有机体和生态学研究的结合揭示了FLOE1作为一种可调节的环境传感器,这在面对气候变化时对抗旱作物的设计具有直接影响。

据了解,许多生物进化出了在干燥环境中生存的策略。植物种子可以保护脱水胚胎免受各种压力因素的影响,并且可以休眠数千年。水合作用是启动萌发的关键触发因素,但种子感知水分的机制仍未得到解决。

附:英文原文

Title: A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation

Author: Yanniv Dorone, Steven Boeynaems, Eduardo Flores, Benjamin Jin, Shannon Hateley, Flavia Bossi, Elena Lazarus, Janice G. Pennington, Emiel Michiels, Mathias De Decker, Katlijn Vints, Pieter Baatsen, George W. Bassel, Marisa S. Otegui, Alex S. Holehouse, Moises Exposito-Alonso, Shahar Sukenik, Aaron D. Gitler, Seung Y. Rhee

Issue&Volume: 2021-07-06

Abstract: Many organisms evolved strategies to survive desiccation. Plant seeds protect dehydratedembryos from various stressors and can lay dormant for millennia. Hydration is thekey trigger to initiate germination, but the mechanism by which seeds sense waterremains unresolved. We identified an uncharacterized Arabidopsis thaliana prion-like protein we named FLOE1, which phase separates upon hydration and allowsthe embryo to sense water stress. We demonstrate that biophysical states of FLOE1condensates modulate its biological function in vivo in suppressing seed germination under unfavorable environments. We find intragenic,intraspecific, and interspecific natural variation in FLOE1 expression and phase separationand show that intragenic variation is associated with adaptive germination strategiesin natural populations. This combination of molecular, organismal, and ecologicalstudies uncovers FLOE1 as a tunable environmental sensor with direct implicationsfor the design of drought-resistant crops, in the face of climate change.

DOI: 10.1016/j.cell.2021.06.009

Source: https://www.cell.com/cell/fulltext/S0092-8674(21)00710-8

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/