当前位置:科学网首页 > 小柯机器人 >详情
一种用于肿瘤消融的蛋白结合分子光热剂
作者:小柯机器人 发布时间:2021/4/4 22:59:50

山东师范大学唐波团队开发了一种用于肿瘤消融的蛋白结合分子光热剂。 相关研究成果于2021年3月30日发表在《德国应用化学》。

光热疗法通常需要较高的功率密度来激活光热剂进行有效治疗,这必然导致正常组织的损伤和肿瘤组织的炎症。

该文中,研究人员合理地设计了一种蛋白质结合策略来构建光热消融肿瘤的分子光热剂。合成的光热剂能与细胞内蛋白质上的巯基共价结合。光热剂产生的热量直接破坏了细胞内的生物活性蛋白质,有效地减少了热量损失和分子泄漏。在0.2w/cm2的低功率密度下,光热剂产生的温度足以诱导细胞凋亡。体内外实验表明,蛋白质结合策略可以有效地提高光热疗法的治疗效果。

附:英文原文

Title: A Protein‐Binding Molecular Photothermal Agent for Tumor Ablation

Author: Mingwan Shi, Zhongliang Fu, Wei Pan, Yuanyuan Chen, Kaiye Wang, Ping Zhou, Na Li, Bo Tang

Issue&Volume: 2021-03-30

Abstract: Photothermal therapy usually requires a high power density to activate photothermal agent for effective treatment, which inevitably leads to damage to normal tissues and inflammation in tumor tissues. Herein, we rationally design a protein‐binding strategy to build a molecular photothermal agent for photothermal ablation of tumor. The synthesized photothermal agent can covalently bind to the thiol groups on the intracellular proteins. The heat generated by the photothermal agent directly destroyed the bioactive proteins in the cells, effectively reducing the heat loss and the molecular leakage. Under a low power density of 0.2 W/cm2, the temperature produced by the photothermal agent was sufficient to induce apoptosis. In vitro and in vivo experiments showed that the therapeutic effect of photothermal therapy can be efficiently improved with the protein‐binding strategy.

DOI: 10.1002/anie.202101009

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202101009

期刊信息

Angewandte Chemie:《德国应用化学》,创刊于1887年。隶属于德国化学会,最新IF:12.959
官方网址:https://onlinelibrary.wiley.com/journal/15213773
投稿链接:https://www.editorialmanager.com/anie/default.aspx