挪威奥斯陆大学医院Pål A. Holme团队研究了ChAdOx1 nCoV-19疫苗接种后的血栓形成和血小板减少症。2021年4月9日，《新英格兰医学杂志》发表了该成果。

研究组报道了5名患者在接种第一剂针对Covid-19的ChAdOx1 nCoV-19腺病毒载体疫苗后7至10天出现静脉血栓形成和血小板减少的研究结果。

患者为32～54岁的医护人员。所有患者的血小板因子4-聚阴离子复合物的抗体水平都很高；但他们此前均未接触过肝素。因为这5个病例发生在超过13万接种疫苗的人群中，研究组认为它们代表了一种罕见的、疫苗相关的、自发性肝素诱导血小板减少症，并称之为疫苗诱导免疫性血小板减少症。

附：英文原文

Title: Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination

Author: Nina H. Schultz, M.D., Ph.D.,, Ingvild H. Srvoll, M.D.,, Annika E. Michelsen, Ph.D.,, Ludvig A. Munthe, M.D., Ph.D.,, Fridtjof Lund-Johansen, M.D., Ph.D.,, Maria T. Ahlen, Ph.D.,, Markus Wiedmann, M.D., Ph.D.,, Anne-Hege Aamodt, M.D., Ph.D.,, Thor H. Skattr, M.D.,, Geir E. Tjnnfjord, M.D., Ph.D.,, and Pl A. Holme, M.D., Ph.D.

Issue&Volume: 2021-04-09

Abstract: We report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). The patients were health care workers who were 32 to 54 years of age. All the patients had high levels of antibodies to platelet factor 4–polyanion complexes; however, they had had no previous exposure to heparin. Because the five cases occurred in a population of more than 130,000 vaccinated persons, we propose that they represent a rare vaccine-related variant of spontaneous heparin-induced thrombocytopenia that we refer to as vaccine-induced immune thrombotic thrombocytopenia.

DOI: 10.1056/NEJMoa2104882

Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2104882